The endocannabinoid system (ECS) is a widespread neuromodulatory network involved in
the developing central nervous system as well as playing a major role in tuning many …

Neurodegeneration leading to Parkinson's disease (PD) and Alzheimer's disease (AD) has
become a major health burden globally. Current treatments mainly target controlling …

Microglia, the resident immune cells in the retina and nervous system, make irreplaceable
contributions to the maintenance of normal homeostasis and immune surveillance of these …

Background Chronic alcohol exposure (CAE) during late adolescence increases the risk of
anxiety development. Alcohol-induced prefrontal cortex (PFC) microglial activation …

The endocannabinoid system (ECS) is a highly versatile signaling system within the nervous
system. Despite its widespread localization, its functions within the context of distinct neural …

Microglia, the resident immune cells of the brain, can take on a range of pro-or anti-
inflammatory phenotypes to maintain homeostasis. However, the sustained activation of pro …

Major depressive disorder is a high-impact, debilitating disease and it is currently
considered the most prevalent mental illness. It is associated with disability, as well as …

Two complex systems are emerging as being deeply involved in the control of energy
metabolism. The intestinal microbiota, with its warehouse of genes, proteins and small …

Microglia are resident immune cells of the brain that survey the microenvironment, provide
trophic support to neurons, and clear debris to maintain homeostasis and healthy brain …

The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors
referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro …