In vitro models of the blood–brain barrier: an overview of commonly used brain endothelial cell culture models and guidelines for their use
The endothelial cells lining the brain capillaries separate the blood from the brain
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …
parenchyma. The endothelial monolayer of the brain capillaries serves both as a crucial …
[HTML][HTML] ABC transporters at the blood–brain interfaces, their study models, and drug delivery implications in gliomas
D Gomez-Zepeda, M Taghi, JM Scherrmann… - Pharmaceutics, 2019 - mdpi.com
Drug delivery into the brain is regulated by the blood–brain interfaces. The blood–brain
barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–arachnoid …
barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–arachnoid …
[HTML][HTML] Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor
JA Brown, V Pensabene, DA Markov, V Allwardt… - …, 2015 - pubs.aip.org
The blood-brain barrier (BBB) is a critical structure that serves as the gatekeeper between
the central nervous system and the rest of the body. It is the responsibility of the BBB to …
the central nervous system and the rest of the body. It is the responsibility of the BBB to …
[HTML][HTML] Functional coupling of human microphysiology systems: intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle
Organ interactions resulting from drug, metabolite or xenobiotic transport between organs
are key components of human metabolism that impact therapeutic action and toxic side …
are key components of human metabolism that impact therapeutic action and toxic side …
[HTML][HTML] Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit
Background Understanding blood-brain barrier responses to inflammatory stimulation (such
as lipopolysaccharide mimicking a systemic infection or a cytokine cocktail that could be the …
as lipopolysaccharide mimicking a systemic infection or a cytokine cocktail that could be the …
[HTML][HTML] Nanogels as novel nanocarrier systems for efficient delivery of CNS therapeutics
Y Zhang, Z Zou, S Liu, S Miao, H Liu - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Nanogels have come out as a great potential drug delivery platform due to its prominently
high colloidal stability, high drug loading, core-shell structure, good permeation property and …
high colloidal stability, high drug loading, core-shell structure, good permeation property and …
[HTML][HTML] Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma
Glioblastoma (GBM), one of the most common primary intracranial malignant tumours, is
very difficult to be completely excised by surgery due to its irregular shape. Here, we use an …
very difficult to be completely excised by surgery due to its irregular shape. Here, we use an …
[HTML][HTML] Role of microvascular disruption in brain damage from traumatic brain injury
AF Logsdon, BP Lucke-Wold, RC Turner… - Comprehensive …, 2015 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is acquired from an external force, which can inflict devastating
effects to the brain vasculature and neighboring neuronal cells. Disruption of vasculature is …
effects to the brain vasculature and neighboring neuronal cells. Disruption of vasculature is …
[HTML][HTML] Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice
C Ozek, RC Krolewski, SM Buchanan, LL Rubin - Scientific reports, 2018 - nature.com
Aging is the biggest risk factor for several neurodegenerative diseases. Parabiosis
experiments have established that old mouse brains are improved by exposure to young …
experiments have established that old mouse brains are improved by exposure to young …
Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes
Accumulating evidence indicates that the active form of vitamin D, 1, 25 (OH) 2D3, can be
considered as a neurosteroid. However, the cerebral expression of vitamin D-associated …
considered as a neurosteroid. However, the cerebral expression of vitamin D-associated …