Pesticides can interact with each other in various ways according to the compound itself and
its chemical family, the dose and the targeted organs, leading to various effects. The term …

Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

This review aims to provide an update on our current knowledge of the various effects of
pesticide cocktails. We have collected data from studies conducted in mammalian models in …

Tetraspanins (Tspans) are a family of four-span transmembrane proteins, known as plasma
membrane “master organizers.” They form Tspan-enriched microdomains (TEMs or TERMs) …

Obesity and nonalcoholic fatty liver disease (NAFLD) can increase susceptibility to
hepatotoxicity induced by some xenobiotics including drugs, but the involved mechanisms …

During the last two decades, the constitutive androstane receptor (CAR; NR1I3) has
emerged as a master activator of drug-and xenobiotic-metabolizing enzymes and …

In vitro cell systems can support hazard characterization and identify mechanisms involved
in toxicity; however, using in vitro data for risk assessment still is challenging. As part of an …

Xenobiotic nuclear receptors (NR) are intracellular players involved in an increasing number
of physiological processes. Examined and characterized in peripheral organs where they …

A number of chemicals have been shown to affect epigenetic patterning and functions. Since
epigenetic mechanisms regulate transcriptional networks, epigenetic changes induced by …

Individuals, typically, are exposed to mixtures of environmental xenobiotics affecting multiple
organs and acting through different xenosensors and pathways in species and cell-type …