Pyridine-based ring systems are one of the most extensively used heterocycles in the field of
drug design, primarily due to their profound effect on pharmacological activity, which has led …

Nonsteroidal anti‐inflammatory drugs (NSAIDs) inhibit the enzyme cyclooxygenase (COX),
which forms prostaglandins involved in pain and inflammation. COX inhibitors have …

Non-steroidal anti-inflammatory drugs (NSAIDs), which act via inhibition of the
cyclooxygenase (COX) isozymes, were discovered more than 100 years ago. They remain a …

Patients with rheumatic diseases, including rheumatoid arthritis and osteoarthritis, almost
universally describe pain and stiffness as important contributors to reduced health-related …

The nonsteroidal anti‐inflammatory drugs (NSAIDs) are commonly prescribed by medical
practitioners in many clinical conditions for the symptomatic treatment of pain and fever. Due …

Objective To examine the cardiovascular risks of diclofenac initiation compared with
initiation of other traditional non-steroidal anti-inflammatory drugs, initiation of paracetamol …

Non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) have been used in clinical
practice for more than a century and are among the most widely used drugs worldwide for …

Acetylsalicylic acid (aspirin) is a prototypic cyclooxygenase (COX) inhibitor. It was
synthesized serendipitously from a natural compound, ie, salicylic acid, with known …

The principal molecular mechanisms underlying the cardiovascular (CV) and renal adverse
effects of nonsteroidal anti-inflammatory drugs (NSAIDs), such as myocardial infarction and …

Objectives: We studied the association between the frequency, dose, and duration of
different nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of myocardial infarction …