Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1

Y Jang, W Kim, P Leblanc, CH Kim… - Experimental & Molecular …, 2021 - nature.com
Abstract Until recently, Nurr1 (NR4A2) was known as an orphan nuclear receptor without a
canonical ligand-binding domain, featuring instead a narrow and tight cavity for small …

Phytotherapeutic effects of the fruits of Poncirus trifoliata (L.) Raf. on cancer, inflammation, and digestive dysfunction

Y Jang, EK Kim, WS Shim - Phytotherapy Research, 2018 - Wiley Online Library
Poncirus trifoliata (L.) Raf. belongs to the family Rutaceae in the genus Poncirus. Its fruits are
widely used to alleviate symptoms of various disorders. The mature fruit (MF) possesses …

Hesperidin improves colonic motility in loeramide-induced constipation rat model via 5-hydroxytryptamine 4R/cAMP signaling pathway

M Wu, Y Li, Y Gu - Digestion, 2020 - karger.com
Fructus has motivation effect on gastrointestinal tract. Hesperidin is extracts of Fructus, and
we attempted to prove its effects on improving the gastrointestinal transmission function and …

Effects of dried Citrus unshiu peels on gastrointestinal motility in rodents

JH Lyu, HT Lee - Archives of pharmacal research, 2013 - Springer
Aqueous extracts of the dried mature (ANP-W) and immature Citrus unshiu peels (CUP-W)
have been used as a traditional folk medicine for the treatment of gastrointestinal (GI) motility …

Poncirus trifoliate fruit modulates pacemaker activity in interstitial cells of Cajal from the murine small intestine

BJ Kim, HW Kim, G San Lee, S Choi, JY Jun… - Journal of …, 2013 - Elsevier
Ethnopharmacological relevance Poncirus fructus (PF) has been widely used as a
traditional medicine in Eastern Asia, especially to ameliorate the symptoms of …

Naringin exhibits in vivo prokinetic activity via activation of ghrelin receptor in gastrointestinal motility dysfunction rats

Y Jang, TK Kim, WS Shim - Pharmacology, 2013 - karger.com
Background and Purpose: Poncirus fructus (PF), also known as the dried immature fruit of
Poncirus trifoliata (L.) Raf., has long been used as a cure for the treatment of various …

Ghrelin receptor is activated by naringin and naringenin, constituents of a prokinetic agent Poncirus fructus

Y Jang, SW Kim, J Oh, GS Hong, EK Seo, U Oh… - Journal of …, 2013 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Poncirus fructus (PF), also known as a dried
immature fruit of Poncirus trifoliata (L.) Raf.(Rutaceae), has long been traditionally used for …

Effects and Safety of Aqueous Extract of Poncirus fructus in Spinal Cord Injury with Neurogenic Bowel

JH Kim, SK Lee, MC Joo - Evidence‐Based Complementary …, 2016 - Wiley Online Library
Objective. To investigate the effects and safety of the aqueous extract of the dried, immature
fruit of Poncirus trifoliata (L.) Raf., known as Poncirus fructus (PF), in spinal cord injury (SCI) …

Emerging drugs for the treatment of gastroparesis

WL Hasler - Expert opinion on emerging drugs, 2014 - Taylor & Francis
Introduction: Gastroparesis presents with symptoms of gastric retention with findings of
delayed gastric emptying on diagnostic testing. Manifestations of gastroparesis are disabling …

Development and validation of an UHPLC-MS/MS method for the simultaneous determination of four flavonoid glycosides and phellopterin in rat plasma: application …

Z Wang, B Qin - Analytical Methods, 2016 - pubs.rsc.org
A simple, sensitive and selective ultra high-performance liquid chromatography-tandem
mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous …