[HTML][HTML] An introduction to spatial transcriptomics for biomedical research
CG Williams, HJ Lee, T Asatsuma, R Vento-Tormo… - Genome Medicine, 2022 - Springer
Single-cell transcriptomics (scRNA-seq) has become essential for biomedical research over
the past decade, particularly in developmental biology, cancer, immunology, and …
the past decade, particularly in developmental biology, cancer, immunology, and …
[HTML][HTML] Applications of single-cell RNA sequencing in drug discovery and development
B Van de Sande, JS Lee, E Mutasa-Gottgens… - Nature Reviews Drug …, 2023 - nature.com
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …
together with associated computational tools and the growing availability of public data …
scGPT: toward building a foundation model for single-cell multi-omics using generative AI
Generative pretrained models have achieved remarkable success in various domains such
as language and computer vision. Specifically, the combination of large-scale diverse …
as language and computer vision. Specifically, the combination of large-scale diverse …
Cross-tissue immune cell analysis reveals tissue-specific features in humans
C Domínguez Conde, C Xu, LB Jarvis, DB Rainbow… - Science, 2022 - science.org
Despite their crucial role in health and disease, our knowledge of immune cells within
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …
FlyBase: a guided tour of highlighted features
LS Gramates, J Agapite, H Attrill, BR Calvi… - Genetics, 2022 - academic.oup.com
FlyBase provides a centralized resource for the genetic and genomic data of Drosophila
melanogaster. As FlyBase enters our fourth decade of service to the research community …
melanogaster. As FlyBase enters our fourth decade of service to the research community …
[HTML][HTML] Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers
H Zhang, L Liu, J Liu, P Dang, S Hu, W Yuan, Z Sun… - Molecular Cancer, 2023 - Springer
In recent years, tumor immunotherapy has made significant progress. However, tumor
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …
[HTML][HTML] From bulk, single-cell to spatial RNA sequencing
X Li, CY Wang - International journal of oral science, 2021 - nature.com
RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in
addition to differential gene expression, thus providing a more complete genetic picture than …
addition to differential gene expression, thus providing a more complete genetic picture than …
Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics
Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but
does not capture their spatial distribution nor reveal local networks of intercellular …
does not capture their spatial distribution nor reveal local networks of intercellular …
Protein-based biological materials: Molecular design and artificial production
Polymeric materials produced from fossil fuels have been intimately linked to the
development of industrial activities in the 20th century and, consequently, to the …
development of industrial activities in the 20th century and, consequently, to the …
Joint probabilistic modeling of single-cell multi-omic data with totalVI
The paired measurement of RNA and surface proteins in single cells with cellular indexing
of transcriptomes and epitopes by sequencing (CITE-seq) is a promising approach to …
of transcriptomes and epitopes by sequencing (CITE-seq) is a promising approach to …