Therapeutic vaccines for HPV-associated malignancies

C Smalley Rumfield, N Roller, ST Pellom… - ImmunoTargets and …, 2020 - Taylor & Francis
Human papillomavirus (HPV)-related malignancies are responsible for almost all cases of
cervical cancer in women, and over 50% of all cases of head and neck carcinoma …

Methods to improve the immunogenicity of plasmid DNA vaccines

D Eusébio, AR Neves, D Costa, S Biswas, G Alves… - Drug Discovery …, 2021 - Elsevier
DNA vaccines have emerged as innovative approaches that have great potential to
overcome the limitations of current conventional vaccines. Plasmid DNA vaccines are often …

Ready for repair? Gene editing enters the clinic for the treatment of human disease

MPT Ernst, M Broeders, P Herrero-Hernandez… - … Therapy Methods & …, 2020 - cell.com
We present an overview of clinical trials involving gene editing using clustered interspaced
short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9), transcription …

Quantitative proteomics reveals a broad‐spectrum antiviral property of ivermectin, benefiting for COVID‐19 treatment

N Li, L Zhao, X Zhan - Journal of Cellular Physiology, 2021 - Wiley Online Library
Viruses such as human cytomegalovirus (HCMV), human papillomavirus (HPV), Epstein–
Barr virus (EBV), human immunodeficiency virus (HIV), and coronavirus (severe acute …

Flavonoids-based delivery systems towards cancer therapies

M Ferreira, D Costa, Â Sousa - Bioengineering, 2022 - mdpi.com
Cancer is the second leading cause of death worldwide. Cervical cancer, for instance, is
considered a major scourge in low-income countries. Its development is mostly associated …

Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes

X Sun, P Fu, L Xie, S Chai, Q Xu… - International …, 2021 - spandidos-publications.com
Resveratrol is a representative polyphenol of diet‑derived putative cancer chemopreventive
agents, which have attracted increasing interest in the cancer chemoprevention community …

In silico approaches: a way to unveil novel therapeutic drugs for cervical cancer management

D Gomes, S Silvestre, AP Duarte, A Venuti, CP Soares… - Pharmaceuticals, 2021 - mdpi.com
Cervical cancer (CC) is the fourth most common pathology in women worldwide and
presents a high impact in developing countries due to limited financial resources as well as …

[HTML][HTML] Development and characterization of quercetin-loaded delivery systems for increasing its bioavailability in cervical cancer cells

M Ferreira, D Gomes, M Neto, LA Passarinha, D Costa… - Pharmaceutics, 2023 - mdpi.com
Quercetin is a natural flavonoid with high anticancer activity, especially for related-HPV
cancers such as cervical cancer. However, quercetin exhibits a reduced aqueous solubility …

Brucine promotes apoptosis in cervical cancer cells (ME‐180) via suppression of inflammation and cell proliferation by regulating PI3K/AKT/mTOR signaling pathway

VD Seshadri - Environmental toxicology, 2021 - Wiley Online Library
Brucine are the main constituents of Strychnos nux‐vomica. Earlier reports have determined
brucine shows anti‐inflammatory, analgesic and excellent anti‐tumor drug. Even though its …

Epigenetic and genetic keys to fight hpv-related cancers

V Folliero, F Dell'Annunziata, A Chianese, MV Morone… - Cancers, 2023 - mdpi.com
Simple Summary Human papillomavirus (HPV) infection is a highly prevalent sexually
transmitted disease globally. Although most HPV infections do not result in cancer, certain …