Conventional chemotherapeutics have been developed into clinically useful agents based
on their ability to preferentially kill malignant cells, generally owing to their elevated …

The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

In recent decades, the increasing interest in the field of immunotherapy has fostered an
intense investigation of the breast cancer (BC) immune microenvironment. In this context …

Immunotherapy is revolutionizing the management of multiple solid tumors, and early data
have revealed the clinical activity of programmed cell death-1/programmed death ligand-1 …

The clinical relevance of the host immune system in breast cancer has long been
unexplored. Studies developed over the past decade have highlighted the biological …

Importance The presence of tumor-infiltrating lymphocytes (TILs) is a favorable prognostic
factor in breast cancer, and TILs may synergize with chemotherapy and immune checkpoint …

Recent years have seen significant efforts in understanding and modulating the immune
response in cancer. In this context, immunosuppressive cells, including regulatory T cells …

Simple Summary The tumor microenvironment (TME) in breast cancer plays important roles
in tumor behavior and treatment response, making its pathologic assessment critical for …

To elucidate the effects of neoadjuvant chemotherapy (NAC), we conduct whole
transcriptome profiling coupled with histopathology analyses of a longitudinal breast cancer …

Tumors develop multiple mechanisms of immune evasion as they progress, with some
cancer types being inherently better at 'hiding'than others. With an increased understanding …