Simple Summary DNA damage is one of the hallmarks of cancer. Epithelial ovarian cancer
(EOC)—especially the high-grade serous subtype—harbors a defect in at least one DNA …

Introduction Radiotherapy is a mainstay of cancer treatment. Clinical studies revealed a
heterogenous response to radiotherapy, from a complete response to even disease …

In cancer cells, poly (ADP-ribose) polymerase (PARP)-1 and PARP2 initiate and regulate
DNA repair pathways to protect against DNA damage and cell death caused by radiotherapy …

Simple Summary This review aims to analyze the emerging issue regarding PARP inhibitor's
resistance in tumors and their consequence on disease prognosis and treatment. Besides …

Cancer treatment with ionizing radiation (IR) is a well-established and effective clinical
method to fight different types of tumors and is a palliative treatment to cure metastatic …

Simple Summary Recent practice-changing trials have highlighted the importance of
polyadenosine diphosphate-ribose polymerase inhibitors (PARPi) in metastatic castrate …

The DNA damage response (DDR) is an elegant system, coordinating DNA repair with cell
cycle checkpoints, that evolved to protect living organisms from the otherwise fatal levels of …

Small cell lung cancer (SCLC) is treated as a monolithic disease despite the evident intra-
and intertumoral heterogeneity. Non-specific DNA-damaging agents have remained the first …

Recently, it was established that ferroptosis, a type of iron-dependent regulated cell death,
plays a prominent role in radiotherapy-triggered cell death. Accordingly, ferroptosis inducers …

Simple Summary While radiotherapy remains a key therapy for many cancers, in recent
years, DNA repair inhibitors, particularly PARP inhibitors, and immunotherapy, specifically …