Accumulating evidence has demonstrated that human cancers arise from various tissues of
origin that initiate from cancer stem cells (CSCs) or cancer-initiating cells. The extrinsic and …

Cyclin-dependent kinases (CDKs) are important regulatory enzymes in the normal
physiological processes that drive cell-cycle transitions and regulate transcription. Virtually …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) possesses strong anti-
cancer potential because of its ability to specifically kill cancer cells. However, clinical use of …

Glioblastoma multiforme (GBM) is a highly aggressive brain cancer with extremely poor
prognostic outcome despite intensive treatment. All chemotherapeutic agents currently used …

Aims Aberrant expression of microRNAs (miRNAs) is frequent in various cancers including
gliomas. We aimed to characterize the role of miR‐16‐5p as a candidate tumour suppressor …

The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) shows a
promising therapeutic potential in cancer treatment as it exclusively causes apoptosis in a …

Large granular lymphocyte (LGL) leukemia results from clonal expansion of CD3+ cytotoxic
T lymphocytes or CD3− natural killer (NK) cells. Chronic antigen stimulation is postulated to …

Cancer cells display a variety of global metabolic changes, which aside from the glycolytic
pathway largely involve amino acid metabolism. To ensure aggressive growth, tumor cells …

Selective killing of cancer cells is one of the major goals of cancer therapy. Although
chemotherapeutic agents are being used for cancer treatment, they lack selectivity toward …

Cardiac glycosides (CGs), prescribed to treat cardiovascular alterations, display potent anti-
cancer activities. Despite their well-established target, the sodium/potassium (Na+/K+) …