The Adenosine diphosphate-Ribosylation Factor (ARF) family belongs to the RAS
superfamily of small GTPases and is involved in a wide variety of physiological processes …

Cell migration and invasion play an important role in the development of cancer. Cell
migration is associated with several specific actin filament–based structures, including …

Small GTPases are a family of low molecular weight GTP-hydrolyzing enzymes that cycle
between an inactive state when bound to GDP and an active state when associated to GTP …

The field of extracellular vesicle (EV) research has rapidly expanded in recent years, with
particular interest in their potential as circulating biomarkers. Proteomic analysis of EVs from …

The fibroblast growth factor 19 gene FGF19 has previously been reported to be amplified in
several cancer types and encodes for a key autocrine signaler known to promote …

For solid tumors, extravasation of cancer cells and their survival in circulation represents a
critical stage of the metastatic process that lacks complete understanding. Gaining insight …

The Golgi complex occupies a strategic position in the endomembrane system and acts not
only as a key trafficking and sorting station and a vital biosynthetic center for glycoproteins …

Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …

We have postulated that the aryl hydrocarbon receptor (AHR) drives the later, more lethal
stages of some cancers when chronically activated by endogenous ligands. However, other …

Background Hepatocellular carcinoma (HCC) has very high prevalence and associated-
mortality. However, targeted therapies that are currently used in clinical practice for HCC …