Targeting monoamine oxidase A: a strategy for inhibiting tumor growth with both immune checkpoint inhibitors and immune modulators

Y Ma, H Chen, H Li, Z Zhao, Q An, C Shi - Cancer Immunology …, 2024 - Springer
Monoamine oxidase A (MAOA) is a membrane-bound mitochondrial enzyme present in
almost all vertebrate tissues that catalyzes the degradation of biogenic and dietary-derived …

Efficient purification of n-butanol by thermally coupled extractive distillation with mixed entrainer

C Pan, X Qiu, J Guo, Y Liu, B Feng, G Li, H Gai… - Separation and …, 2024 - Elsevier
To solve the problems of difficult separation of azeotropes and high energy consumption in
the preparation of n-butanol from the fermented mother liquor, this study focused on the …

Abraham Model descriptors for vitamin K4: prediction of solution, biological and thermodynamic properties

S Motati, R Motati, T Kandi, WE Acree Jr - Liquids, 2023 - mdpi.com
Spectrophotometric measurements were used to determine the mole fraction solubilities of
vitamin K4 dissolved in cyclohexane, methylcyclohexane, 1-heptanol, 2-butanol, 2-pentanol …

Machine learning approach to predict Hansen solubility parameters of cocrystal coformers via integrating group contribution and COSMO-RS

C Li, Z Li, X Liu, J Xu, C Zhang - Journal of Molecular Liquids, 2024 - Elsevier
Abstract Hansen Solubility Parameters (HSPs) have been a hot topic on predicting the
tendency of pharmaceutical cocrystals formation and cocrystal coformers (CCFs) screening …

A Machine Learning Approach for the Prediction of Aqueous Solubility of Pharmaceuticals: A Comparative Model and Dataset Analysis

MA Ghanavati, S Ahmadi, S Rohani - Digital Discovery, 2024 - pubs.rsc.org
The effectiveness of drug treatments depends significantly on the water solubility of
compounds, influencing bioavailability and therapeutic outcomes. A reliable predictive …

Towards the Prediction of Drug Solubility in Binary Solvent Mixtures at Various Temperatures Using Machine Learning

Z Bao, G Tom, A Cheng, A Aspuru-Guzik, C Allen - 2024 - researchsquare.com
Drug solubility plays an important role in the drug development process. Traditional methods
for measuring solubility involve saturating a solvent with the drug and determining the drug …