The fructose survival hypothesis for obesity

RJ Johnson, MA Lanaspa… - … of the Royal …, 2023 - royalsocietypublishing.org
The fructose survival hypothesis proposes that obesity and metabolic disorders may have
developed from over-stimulation of an evolutionary-based biologic response (survival …

A high-sugar diet consumption, metabolism and health impacts with a focus on the development of substance use disorder: a narrative review

K Witek, K Wydra, M Filip - Nutrients, 2022 - mdpi.com
Carbohydrates are important macronutrients in human and rodent diet patterns that play a
key role in crucial metabolic pathways and provide the necessary energy for proper body …

[HTML][HTML] Purine metabolism in the development of osteoporosis

K Yang, J Li, L Tao - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Osteoporosis is a common bone metabolic disease in postmenopausal women, diabetic
patients and obese patients and is characterized by an imbalance in bone formation and …

[HTML][HTML] Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism?

RJ Johnson, DR Tolan, D Bredesen, M Nagel… - The American Journal of …, 2023 - Elsevier
An important aspect of survival is to assure enough food, water, and oxygen. Here, we
describe a recently discovered response that favors survival in times of scarcity, and it is …

Mini review: reappraisal of uric acid in chronic kidney disease

A Goldberg, F Garcia-Arroyo, F Sasai… - American journal of …, 2021 - karger.com
Hyperuricemia predicts the development of chronic kidney disease (CKD) and metabolic
complications, but whether it has a causal role has been controversial. This is especially true …

Diet, gut microbiome, and cognitive decline

S Ettinger - Current Nutrition Reports, 2022 - Springer
Abstract Purpose of Review An epidemic of age-associated cognitive decline, most
commonly ascribed to neurodegenerative conditions such as Alzheimer's and Parkinson's …

Fucoidan ameliorates LPS-induced neuronal cell damage and cognitive impairment in mice

Y Wang, Q Wang, L Duan, X Li, W Yang… - International Journal of …, 2022 - Elsevier
The incidence of cognitive impairment is rising globally, but there is no effective therapy.
Recent studies showed that fucoidan (Fuc), a sulfated polysaccharide enriched in brown …

Neural mechanisms underlying the role of fructose in overfeeding

MA Payant, MJ Chee - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Fructose consumption has been linked with metabolic syndrome and obesity. Fructose-
based sweeteners like high fructose corn syrup taste sweeter, improve food palatability, and …

Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites

BK Ball, MK Kuhn, RM Fleeman Bechtel, EA Proctor… - Scientific Reports, 2024 - nature.com
Abstract Type 2 diabetes (T2D) is implicated as a risk factor for Alzheimer's disease (AD), the
most common form of dementia. In this work, we investigated neuroinflammatory responses …

Breakfast: A crucial meal for adolescents' cognitive performance according to their nutritional status. The cogni-action project

H Peña-Jorquera, V Campos-Núñez, KP Sadarangani… - Nutrients, 2021 - mdpi.com
This study aimed to determine whether pupils who have breakfast just before a cognitive
demand, do not regularly skip breakfast, and consume a high-quality breakfast present …