Nitrogen heterocycles have found a key role in biologically active natural products.
Pyridones, specifically 2‐pyridone and 2, 4‐dihydoxypyridine are an extensive class of …

We report a novel strategy for the formal activation of sp3 C–O bonds under Ru catalysis. In
this reaction, an O-alkylpyridine undergoes migratory rearrangement to its corresponding N …

We have identified an enantioselective copper-catalyzed O-to-N formal [1, 3]-rearrangement
to form N-propargylic-2-pyridones. This enantioconvergent O-to-N propargylic …

A mild and regioselective N-alkylation reaction of 2-pyridones in water has been developed.
Tween 20 (2% w/w) was added to create a micellar system for improved solubility of starting …

A selective N-alkylation reaction of 2-pyridones and related heterocycles via intermolecular
alkene hydroamination is reported. The reaction utilizes palladium (II) acetate as a catalyst …

Previously we reported the discovery of CRA-898 (1), a diazine indole acetic acid containing
CRTH2 antagonist. This compound had good in vitro and in vivo potency, low rates of …

A new LiI-promoted O-to N-alkyl migration has been developed for the conversion of O-
alkylated 2-hydroxy pyridines, quinolines, and pyrimidines to the corresponding N-alkylated …

A novel cascade cyclisation protocol has been developed which 'zips up'two rings to form
new tetracycles. In the protocol, treatment of vinyl bromides and iodides with hexamethylditin …

A cationic Ir (I) complex-catalyzed O-to-N-alkyl migration in 2-alkoxypyridines bearing a
secondary alkyl group on the oxygen atom by C–O bond cleavage is described. The present …

A general and simple method for the preparation of under explored 3-aryl-4-
hydroxyfuroxans by nucleophilic substitution of the nitro group in 3-aryl-4-nitrofuroxans …