The complexity of NF-κB signaling in inflammation and cancer
The NF-κB family of transcription factors has an essential role in inflammation and innate
immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of …
immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of …
Cullin-RING Ligases as attractive anti-cancer targets
The ubiquitin-proteasome system (UPS) promotes the timely degradation of short-lived
proteins with key regulatory roles in a vast array of biological processes, such as cell cycle …
proteins with key regulatory roles in a vast array of biological processes, such as cell cycle …
A mitochondrial SCF‐FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease
Y Cao, J Zheng, H Wan, Y Sun, S Fu, S Liu, B He… - The EMBO …, 2023 - embopress.org
Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory
mechanisms and pathological implications remain poorly understood. Here, via a …
mechanisms and pathological implications remain poorly understood. Here, via a …
Nedd8 on cullin: building an expressway to protein destruction
This review summarizes recent advances concerning the Nedd8 regulatory pathway in four
areas. One, substantial progress has been made in delineating the role of cullin family …
areas. One, substantial progress has been made in delineating the role of cullin family …
Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action
SC Miller, R Huang, S Sakamuru, SJ Shukla… - Biochemical …, 2010 - Elsevier
Nuclear factor-kappa B (NF-κB) is a transcription factor that plays a critical role across many
cellular processes including embryonic and neuronal development, cell proliferation …
cellular processes including embryonic and neuronal development, cell proliferation …
[PDF][PDF] CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex
J Zheng, X Yang, JM Harrell, S Ryzhikov, EH Shim… - Molecular cell, 2002 - cell.com
The SCF ubiquitin E3 ligase regulates ubiquitin-dependent proteolysis of many regulatory
proteins such as p27 Kip1, IκB, and β-catenin. We report the isolation of a CUL1 binding …
proteins such as p27 Kip1, IκB, and β-catenin. We report the isolation of a CUL1 binding …
[HTML][HTML] Destruction of Claspin by SCFβTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
We show that Claspin, an adaptor protein required for Chk1 activation, becomes degraded
at the onset of mitosis. Claspin degradation was triggered by its interaction with, and …
at the onset of mitosis. Claspin degradation was triggered by its interaction with, and …
[PDF][PDF] The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation
Recent genetic studies have documented a pivotal growth-regulatory role played by the
Cullin 7 (CUL7) E3 ubiquitin ligase complex containing the Fbw8-substrate-targeting …
Cullin 7 (CUL7) E3 ubiquitin ligase complex containing the Fbw8-substrate-targeting …
Proteomic analyses reveal distinct chromatin‐associated and soluble transcription factor complexes
The current knowledge on how transcription factors (TF s), the ultimate targets and executors
of cellular signalling pathways, are regulated by protein–protein interactions remains limited …
of cellular signalling pathways, are regulated by protein–protein interactions remains limited …
[HTML][HTML] SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53
Mdm2 is an E3 ubiquitin ligase for the p53 tumor suppressor protein. We demonstrate that
Mdm2 is conjugated with SUMO-1 (sumoylated) at Lys-446, which is located within the RING …
Mdm2 is conjugated with SUMO-1 (sumoylated) at Lys-446, which is located within the RING …