Isobiotic mice, with an identical stable microbiota composition, potentially allow models of
host-microbial mutualism to be studied over time and between different laboratories. To …

The human intestine harbors an immense, diverse, and critical population of bacteria that
has effects on numerous aspects of host physiology, immunity, and disease. Emerging …

The early life immune system is characterized by unique developmental milestones.
Functionally diverse immune cells arise from distinct waves of hematopoietic stem cells, a …

The gastrointestinal (GI) tract is a highly complex organ composed of the intestinal
epithelium layer, intestinal microbiota, and local immune system. Intestinal microbiota …

The enteric nervous system is largely autonomous, and the central nervous system is
compartmentalized behind the blood-brain barrier. Yet the intestinal microbiota shapes gut …

Humans with the metabolic syndrome and type 2 diabetes have an altered gut microbiome.
Emerging evidence indicates that it is not only the microorganisms and their structural …

Immunoglobulin (Ig) A controls host-microbial homeostasis in the gut. IgA recognition of
beneficial bacteria is decreased in acutely undernourished children, but the factors driving …

Single-nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35
(GPR35) are associated with increased risk of inflammatory bowel disease. However, the …

The human body supports a thriving diversity of microbes which comprise a dynamic,
ancillary, functional system that synergistically develops in lock-step with physiological …

Background & Aims Depression and anxiety are frequent comorbidities with inflammatory
bowel diseases (IBD). Alterations to the intestinal microbiome promote not only intestinal …