The yin and yang of human soil-transmitted helminth infections

A Loukas, RM Maizels, PJ Hotez - International journal for parasitology, 2021 - Elsevier
The major soil-transmitted helminths that infect humans are the roundworms, whipworms
and hookworms. Soil-transmitted helminth infections rank among the most important …

The mRNA vaccine technology era and the future control of parasitic infections

H You, MK Jones, CA Gordon… - Clinical Microbiology …, 2023 - Am Soc Microbiol
Despite intensive long-term efforts, with very few exceptions, the development of effective
vaccines against parasitic infections has presented considerable challenges, given the …

[HTML][HTML] Soil-transmitted helminths: A critical review of the impact of co-infections and implications for control and elimination

S Lebu, W Kibone, CC Muoghalu… - PLoS neglected …, 2023 - journals.plos.org
Researchers have raised the possibility that soil-transmitted helminth (STH) infections might
modify the host's immune response against other systemic infections. STH infections can …

[HTML][HTML] Communication is key: Innate immune cells regulate host protection to helminths

J Peng, HG Federman, CM Hernandez… - Frontiers in …, 2022 - frontiersin.org
Parasitic helminth infections remain a significant global health issue and are responsible for
devastating morbidity and economic hardships. During infection, helminths migrate through …

Why are we still a worm world in the 2020s? an overview of risk factors and endemicity for soil-transmitted helminthiasis

AFR Neto, YL Di Christine Oliveira, LM De Oliveira… - Acta parasitologica, 2023 - Springer
Purpose Soil-transmitted helminthiasis (STH) is one of the most common chronic infections
in developing countries associated with poor socioeconomic and sanitary conditions. The …

[HTML][HTML] Whipworm secretions and their roles in host-parasite interactions

RK Shears, RK Grencis - Parasites & Vectors, 2022 - Springer
Whipworm (Trichuris) is a genus of roundworms that causes gastrointestinal infections in
humans and animals. Of particular interest are T. trichiura, the causative agent of human …

Soil-transmitted helminthic vaccines: Where are we now?

MTJ Wong, NS Anuar, R Noordin, GJ Tye - Acta tropica, 2023 - Elsevier
It has been tested and proven that vaccination is still the best strategy to combat infectious
diseases. However, to date, there are still no vaccines against human soil-transmitted …

[HTML][HTML] In silico design of a polypeptide as a vaccine candidate against ascariasis

FMD Evangelista, AHM van Vliet, SP Lawton… - Scientific reports, 2023 - nature.com
Ascariasis is the most prevalent zoonotic helminthic disease worldwide, and is responsible
for nutritional deficiencies, particularly hindering the physical and neurological development …

[HTML][HTML] Innovative ecosystem model of vaccine lifecycle management

I Ilin, A Levina, K Frolov - Journal of Open Innovation: Technology, Market …, 2022 - mdpi.com
The COVID-19 pandemic has severely tested humanity, revealing the need to develop and
improve the medical, economic, managerial, and IT components of vaccine management …

[HTML][HTML] Community-wide mass drug administration for soil-transmitted helminths–risk of drug resistance and mitigation strategies

N Pilotte, M Manuel, JL Walson… - Frontiers in Tropical …, 2022 - frontiersin.org
Mass drug administration programs for the control of soil-transmitted helminths (STH) in
humans most commonly utilize a single class of drugs; the benzimidazoles. Most such …