Breast cancer emerges by a multistep process which can be broadly equated to
transformation of normal cells via the steps of hyperplasia, premalignant change and in situ …

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Comparative genomic hybridization (CGH) reveals DNA sequence copy number changes
that are shared among the different cell subpopulations present in a tumor and may help to …

In a separate study (F. Courjal et al., Cancer Res., 57: 4360–4367, 1997), we have analyzed
by Southern blotting the relationship between DNA amplification and clinicopathological …

Deletions of genomic regions involving tumor suppressor genes are thought to be important
in the initiation and progression of breast cancer. We conducted a genome-wide search for …

Deletions and rearrangements involving chromosome 6q have been reported in a number of
human cancers such as ovarian and breast tumors as well as melanoma and hemopoietic …

Loss of heterozygosity (LOH) was evaluated in 174 breast and ovarian tumors derived from
94 families with at least 3 first‐degree relatives affected with either of these cancers. By …

The development of familial and sporadic breast cancer is based on genetic alterations of
tumour-suppressor genes, for which loss of heterozygosity (LOH) is one mechanism of gene …

The association found between breast cancer development and prolonged exposure to
estrogen suggests that this hormone is of etiologic importance in the causation of this …

Haldane's sieve posits that the majority of beneficial mutations that contribute to adaptation
should be dominant, as these are the mutations most likely to establish and spread when …