Breast‐carcinoma development presumably results from multiple mutational events in tumor‐
associated genes. Certain results indicate that some tumor‐suppressor genes may combine …

Defining boundaries of chromosomal rearrangements at the molecular level would benefit
from landmarks that link the cytogenetic map to physical, genetic, and transcript maps, as …

Breast cancer emerges as a multistep process with transformation of normal cells via steps
of hyperplasia, premalignant change and in situ carcinoma. Cytogenetic and molecular …

Purpose: Local control rates for breast cancer in genetically predisposed women are poorly
defined. Because such a small percentage of breast cancer patients have proven germline …

Genetic abnormalities of chromosome 17 are frequently found in human breast cancer.
Recently, loss of heterozygosity (LOH) and microsatellite instability (MSI) studies have …

The proportions of mutation of BRCA1 and BRCA2 detected in familial breast cancer vary in
different regions. Most breast cancer families in Sweden cannot be explained by mutations …

Benzo [a] pyrenediol-epoxide (BPDE), a metabolite of the ubiquitous environmental
carcinogen benzo [a] pyrene (B [a] P), has been implicated as a point mutagen. However, as …

To understand the genetic basis of breast cancer in a comprehensive way, purported
precursor lesions need to be analyzed at a large number of genetic marker loci and …

How different the practice of oncology would become if physicians could predict which of
their patients will develop cancer, and, if the disease does occur, then determine who might …

Breast cancer susceptibility genes are being isolated at a rapid pace. Current molecular
diagnostic techniques are being adapted to detect mutations in the germline and in tumors …