Nasal Delivery to the Brain: Harnessing Nanoparticles for Effective Drug Transport

S Gandhi, DH Shastri, J Shah, AB Nair, S Jacob - Pharmaceutics, 2024 - mdpi.com
The nose-to-brain drug-delivery system has emerged as a promising strategy to overcome
the challenges associated with conventional drug administration for central nervous system …

Development of hyaluronic acid-based microneedles for improved brain delivery of rivastigmine nanoparticles via mystacial pad region

AD Permana, AYR Aziz, A Sam, YY Djabir… - Journal of Drug Delivery …, 2023 - Elsevier
In this study, for the first time, we developed the novel combinatorial approach of poly-lactid-
co-glycolid acid (PLGA)-based nanoparticles (PLGA-NPs) containing rivastigmine (RV) and …

[HTML][HTML] PLGA nanoparticles for nasal drug delivery

S Alghareeb, K Asare-Addo, BR Conway… - Journal of Drug Delivery …, 2024 - Elsevier
The nasal route has routinely been used in the local delivery of drugs, however with
innovations in nanotechnology, there has been increased interest in exploring this route …

PLGA Nanoparticles Based Mucoadhesive Nasal In Situ Gel for Enhanced Brain Delivery of Topiramate

V Tanna, A Vora, P Shah, AB Nair, J Shah… - AAPS …, 2024 - Springer
Oral Topiramate therapy is associated with systemic adverse effects including paresthesia,
abdominal pain, and fluctuations in plasma levels. The purpose of this research was to …

Activates B lymphocytes and enhanced immune response: A promising adjuvant based on PLGA nanoparticle to improve the sensitivity of ZEN monoclonal antibody

C Pang, B Yuan, K Ren, H Xu, K Nie, C Yu, Z Liu… - Talanta, 2024 - Elsevier
In preparing monoclonal antibodies by hybridoma cell technology, the quality of B
lymphocytes used for cell fusion directly affects the sensitivity of monoclonal antibodies. To …

Preparation and characterization of PLGA nano-drug delivery system co-loaded with tranilast/gallium phytate for stent coating

K Wen, Z Li, J Liu, C Zhang, F Zhang, F Li - Journal of Drug Delivery …, 2024 - Elsevier
The implantation of bare metal ureteral stents may lead to bacterial colonization and scar
hyperplasia. To effectively address these issues, PLGA nanoparticles co-loaded with …

Surface modified PLGA nanoparticles of gabapentin: Biodistribution and pharmacodynamic investigation via intranasal route

G Rai, P Gauba, A Tyagi, S Dang - Journal of Drug Delivery Science and …, 2024 - Elsevier
Epilepsy is a chronic condition and is caused by abnormal electrical conduction by nerve
cells. It can affect people from different age groups. The prime objective of epilepsy …

Surface-Active Ligands for Brain Targeting

M Zewail, H Abd-El-Azim - Nanocarriers in Neurodegenerative …, 2024 - taylorfrancis.com
This book chapter looks into the fascinating field of surface-active ligands that are
specifically engineered to accurately and efficiently deliver therapeutic medicines to the …