Comprehensive review on various strategies for antimalarial drug discovery

M Mishra, VK Mishra, V Kashaw, AK Iyer… - European journal of …, 2017 - Elsevier
The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

Malaria: an update on current chemotherapy

BJ Visser, M van Vugt, MP Grobusch - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Chemotherapy of malaria has become a rapidly changing field. Less than two
decades ago, treatment regimens were increasingly bound to fail due to emerging drug …

First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: a meta-analysis of observational studies

S Dellicour, E Sevene, R McGready, H Tinto… - PLoS …, 2017 - journals.plos.org
Background Animal embryotoxicity data, and the scarcity of safety data in human
pregnancies, have prevented artemisinin derivatives from being recommended for malaria …

Drug treatment and prevention of malaria in pregnancy: a critical review of the guidelines

KAJ Al Khaja, RP Sequeira - Malaria journal, 2021 - Springer
Abstract Background Malaria caused by Plasmodium falciparum in pregnancy can result in
adverse maternal and fetal sequelae. This review evaluated the adherence of the national …

New approaches in antimalarial drug discovery and development: a review

ACC Aguiar, EMM da Rocha, NB de Souza… - Memorias do Instituto …, 2012 - SciELO Brasil
Malaria remains a major world health problem following the emergence and spread of
Plasmodium falciparum that is resistant to the majority of antimalarial drugs. This problem …

Antimalarial chemotherapy: natural product inspired development of preclinical and clinical candidates with diverse mechanisms of action: miniperspective

E Fernandez-Alvaro, WD Hong, GL Nixon… - Journal of medicinal …, 2016 - ACS Publications
Natural products have played a pivotal role in malaria chemotherapy progressing from
quinine and artemisinin to ozonide-based compounds. Many of these natural products have …

Addressing barriers to the development and adoption of rapid diagnostic tests in global health

E Miller, HD Sikes - Nanobiomedicine, 2015 - hrcak.srce.hr
Sažetak Immunochromatographic rapid diagnostic tests (RDTs) have demonstrated
significant potential for use as point-of-care diagnostic tests in resource-limited settings …

Practical gram-scale synthesis of iboxamycin, a potent antibiotic candidate

JD Mason, DW Terwilliger, AR Pote… - Journal of the American …, 2021 - ACS Publications
A gram-scale synthesis of iboxamycin, an antibiotic candidate bearing a fused bicyclic
amino acid residue, is presented. A pivotal transformation in the route involves an …

Malaria therapeutics: are we close enough?

H Tripathi, P Bhalerao, S Singh, H Arya, BS Alotaibi… - Parasites & …, 2023 - Springer
Malaria is a vector-borne parasitic disease caused by the apicomplexan protozoan parasite
Plasmodium. Malaria is a significant health problem and the leading cause of …

An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins

H Madhav, N Hoda - European Journal of Medicinal Chemistry, 2021 - Elsevier
Malaria is an endemic disease, prevalent in tropical and subtropical regions which cost half
of million deaths annually. The eradication of malaria is one of the global health priority …