Schizophrenia is a widespread psychiatric disorder that affects 0.5–1.0% of the world's
population and induces significant, long-term disability that exacts high personal and …

Recently, the abuse of ketamine has soared. Therefore, it is of great importance to study its
potential risks. The effects of prolonged ketamine on the brain can be observationally …

A single sub-anesthetic dose of ketamine produces a rapid and sustained antidepressant
response, yet the molecular mechanisms responsible for this remain unclear. Here, we …

The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …

Background and aims Long-term alcohol intake leads to cognitive impairment and dementia.
The impairment of the cerebral cortex and limbic structures in alcoholics is associated with …

Posttraumatic stress disorder (PTSD) is a devastating medical illness, for which currently
available pharmacotherapies have poor efficacy. Accumulating evidence from clinical and …

Depressive disorders (DDs) are an increasingly common health problem that affects all age
groups. DDs pathogenesis is multifactorial. However, it was proven that stress is one of the …

Ketamine recently approved for therapy of treatment-resistant depression shows a complex
and not fully understood mechanism of action. Apart from its classical glutamatergic N …

Suicide is a major global hazard. There is a need for increasing suicide awareness and
effective and evidence-based interventions, targeting both suicidal ideation and conduct …

The pathophysiological mechanisms underlying bipolar (BD) and major depressive
disorders (MDD) are multifactorial but likely involve synaptic dysfunction and dysregulation …