Much of systems biology aims to predict the behaviour of biological systems on the basis of
the set of molecules involved. Understanding the interactions between these molecules is …

Src homology 2 (SH2) domains are 100 amino acid modular units, which recognize and
bind to tyrosyl-phosphorylated peptide sequences on their target proteins, and thereby …

We report a method of photo-cross-linking proteins in mammalian cells, which is based on
site-specific incorporation of a photoreactive amino acid, p-benzoyl-l-phenylalanine (p Bpa) …

Succinate-and cyclopropane-derived phosphotyrosine (pY) replacements were incorporated
into a series of Grb2 SH2 binding ligands wherein the pY+ 1 residue was varied to …

Virtually every process in a cell is carried out by macromolecular complexes whose actions
need to be perfectly orchestrated. The synchronization and regulation of these biological …

Three-dimensional structures are now known within most protein families and it is likely,
when searching a sequence database, that one will identify a homolog of known structure …

Apicomplexan parasites use a specialized cilium structure called the apical complex to
organize their secretory organelles and invasion machinery. The apical complex is integrally …

Cellular functions require specific protein-protein interactions that are often mediated by
modular domains that use binding pockets to engage particular sequence motifs in their …

The thermodynamic and structural effects of macrocyclization as a tactic for stabilizing the
biologically active conformation of Grb2 SH2 binding peptides were investigated using …

Mutations, which result in amino acid substitutions, influence the stability of proteins and
their binding to biomolecules. A molecular understanding of the effects of protein mutations …