Childhood maltreatment is a stressor that can lead to the development of behavior problems
and affect brain structure and function. This review summarizes the current evidence for the …

Borderline personality disorder is characterised by a pervasive pattern of instability in affect
regulation, impulse control, interpersonal relationships, and self-image. Clinical signs of the …

BACKGROUND: Converging evidence from animal and human lesion studies implicates the
amygdala and orbitofrontal cortex (OFC) in emotional regulation and aggressive behavior …

Pathological dissociation is a severe, debilitating and transdiagnostic psychiatric symptom.
This review identifies biomarkers of pathological dissociation in a transdiagnostic manner to …

Childhood trauma has been associated with long term effects on prefrontal-limbic grey
matter. A literature search was conducted to identify structural magnetic resonance imaging …

The aim of this chapter is to describe the application and the theoretical rationale of a set of
emotion regulation skills developed within the context of dialectical behavior therapy (DBT) …

BACKGROUND: Emotional vulnerabilities at the core of borderline personality disorder
(BPD) involve a dysfunction of frontolimbic systems subserving negative emotionality. The …

BACKGROUND: In a range of species, the androgen steroid testosterone is known to
potentiate neural circuits involved in intraspecific aggression. Disorders of impulsive …

The neuropsychological profile of borderline personality disorder (BPD) is unclear. Past
investigations have produced seemingly inconsistent results concerning precisely what …

A neurobiologically informed approach to a very difficult-to-treat disorder. This book
addresses one of the fundamental, understudied issues of borderline personality disorder …