The intestinal barrier is essential in human health and constitutes the interface between the
outside and the internal milieu of the body. A functional intestinal barrier allows absorption of …

The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the …

Chron's Disease is a chronic inflammatory intestinal disease, first described at the beginning
of the last century. The disease is characterized by the alternation of periods of flares and …

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are
complex diseases that result from the chronic dysregulated immune response in the …

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has
risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an …

Studies on monocyte and macrophage biology and differentiation have revealed the
pleiotropic activities of these cells. Macrophages are tissue sentinels that maintain tissue …

The intestine represents the largest compartment of the immune system. It is continually
exposed to antigens and immunomodulatory agents from the diet and the commensal …

The pathogenesis of inflammatory bowel disease (IBD) is still unclear. Immune dysfunction
may play a key role in the pathogenesis of IBD, in which the role of CD4+ T helper (Th) cells …

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder with an
unknown etiology. IBD is composed of two different disease entities: Crohn's disease (CD) …

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract with a multifactorial pathophysiology. Full comprehension of IBD pathology is still out of …