Growth hormone-secreting pituitary adenomas that cause acromegaly arise as monoclonal
expansions of differentiated somatotroph cells and are usually sporadic. They are almost …

Acromegaly is typically caused by a growth hormone–secreting pituitary adenoma, driving
excess secretion of insulin-like growth factor 1. Acromegaly may result in a variety of …

Abstract Purpose The 14th Acromegaly Consensus Conference was convened to consider
biochemical criteria for acromegaly diagnosis and evaluation of therapeutic efficacy …

An important aspect of precision medicine is to probe the stability in molecular profiles
among healthy individuals over time. Here, we sample a longitudinal wellness cohort with …

GPR101 is an orphan G protein-coupled receptor actively participating in energy
homeostasis. Here we report the cryo-electron microscopy structure of GPR101 …

Context Somapacitan, a once-weekly reversible albumin-binding GH derivative, is evaluated
in children with GH deficiency (GHD). Objective To demonstrate efficacy and safety of …

Insulin like growth factor-1 (IGF-1) plays important roles in metabolic functions, especially in
adulthood. Additionally, obese subjects are reportedly predisposed to having low absolute …

Growth hormone and its mediator insulin‐like growth factor‐1 exert their effect on different
organs and control various physiologic metabolic processes. Adult growth hormone …

Context Growth hormone (GH) replacement requires daily GH injections, which is
burdensome for some adult patients with GH deficiency (AGHD). Objective To demonstrate …

The homeostasis of bone microenvironment is the foundation of bone health and comprises
2 concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In …