Atherosclerotic cardiovascular diseases (ASCVD), including coronary artery disease,
cerebrovascular disease, and peripheral arterial disease, represent a significant cause of …

Obesity is a public health problem that has reached epidemic proportions with an increasing
worldwide prevalence. The global emergence of obesity increases the risk of developing …

Platelets are small anucleate cell fragments that circulate in blood playing crucial role in
managing vascular integrity and regulating hemostasis. Platelets are also involved in the …

Atherosclerosis is an inflammatory disease. Because high plasma concentrations of
cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the …

In the mid 1990s, immunoassays for C-reactive protein (CRP), with greater sensitivity than
those previously in routine use, revealed that increased CRP values, even within the range …

Background Inflammation may be important in the pathogenesis of atherothrombosis. We
studied whether inflammation increases the risk of a first thrombotic event and whether …

C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of
interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown …

Defining new approaches for the prevention and treatment of atherosclerosis is an important
priority. Recently, measurement of endothelial function in patients has emerged as a useful …

Context.—A large number of epidemiologic studies have reported on associations between
various" inflammatory" factors and coronary heart disease (CHD). Objective.—To assess the …

Background Cigarette smoking and abnormal serum cholesterol concentrations are risk
factors for acute coronary syndromes, but the underlying mechanisms are poorly …