Common variable immunodeficiency: more pathways than roads to Rome
XP Peng, A Caballero-Oteyza… - Annual Review of …, 2023 - annualreviews.org
Fifty years have elapsed since the term common variable immunodeficiency (CVID) was
introduced to accommodate the many and varied antibody deficiencies being identified in …
introduced to accommodate the many and varied antibody deficiencies being identified in …
Bioinformatic and statistical analysis of adaptive immune repertoires
High-throughput sequencing (HTS) of immune repertoires has enabled the quantitative
analysis of adaptive immune responses and offers the potential to revolutionize research in …
analysis of adaptive immune responses and offers the potential to revolutionize research in …
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
Local immune response to food antigens drives meal-induced abdominal pain
J Aguilera-Lizarraga, MV Florens, MF Viola, P Jain… - Nature, 2021 - nature.com
Up to 20% of people worldwide develop gastrointestinal symptoms following a meal, leading
to decreased quality of life, substantial morbidity and high medical costs. Although the …
to decreased quality of life, substantial morbidity and high medical costs. Although the …
Modeling human adaptive immune responses with tonsil organoids
LE Wagar, A Salahudeen, CM Constantz, BS Wendel… - Nature medicine, 2021 - nature.com
Most of what we know about adaptive immunity has come from inbred mouse studies, using
methods that are often difficult or impossible to confirm in humans. In addition, vaccine …
methods that are often difficult or impossible to confirm in humans. In addition, vaccine …
High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes
High-throughput single-cell RNA sequencing is a powerful technique but only generates
short reads from one end of a cDNA template, limiting the reconstruction of highly diverse …
short reads from one end of a cDNA template, limiting the reconstruction of highly diverse …
Longitudinal analysis of the human B cell response to Ebola virus infection
Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B
cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection …
cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection …
Origins and clonal convergence of gastrointestinal IgE+ B cells in human peanut allergy
RA Hoh, SA Joshi, JY Lee, BA Martin, S Varma… - Science …, 2020 - science.org
B cells in human food allergy have been studied predominantly in the blood. Little is known
about IgE+ B cells or plasma cells in tissues exposed to dietary antigens. We characterized …
about IgE+ B cells or plasma cells in tissues exposed to dietary antigens. We characterized …
Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues
Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B
cells, which encode humoral immune memory. We evaluated pediatric and adult blood and …
cells, which encode humoral immune memory. We evaluated pediatric and adult blood and …
Current understanding and recent developments in common variable immunodeficiency associated autoimmunity
JD Gereige, PJ Maglione - Frontiers in immunology, 2019 - frontiersin.org
Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary
immunodeficiency and comprises a group of disorders with similar antibody deficiency but a …
immunodeficiency and comprises a group of disorders with similar antibody deficiency but a …