Epigenetic modifications could drive some of the molecular events implicated in
proliferation, drug resistance and metastasis of pancreatic ductal adenocarcinoma (PDAC) …

Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling
of small pulmonary arteries (PAs) causing sustained elevation of PA pressure, right …

Renal cell carcinoma accounts for 2–3% of all cancers. It is difficult to diagnose early.
Recently, genome-wide studies have identified that histone methylation was one of the …

In recent years, histone methyltransferases (HMTs) have emerged as important therapeutic
targets in cancer due to their oncogenic role. Herein, we used the GLP/G9a inhibitor …

G9a is a lysine methyltransferase that has been reported to downregulate the expression of
tumor suppressor genes in a variety of cancerous cells. The present study explores the anti …

This project arose motivated by the high incidence that neoplastic pathologies have
nowadays, and therefore by the need that our society has to find a solution against them …