Oral nanomedicine: challenges and opportunities

B Deng, S Liu, Y Wang, B Ali, N Kong, T Xie… - Advanced …, 2024 - Wiley Online Library
Compared to injection administration, oral administration is free of discomfort, wound
infection, and complications and has a higher compliance rate for patients with diverse …

Oral nanomedicine biointeractions in the gastrointestinal tract in health and disease

C Chen, A Beloqui, Y Xu - Advanced drug delivery reviews, 2023 - Elsevier
Oral administration is the preferred route of administration based on the convenience for and
compliance of the patient. Oral nanomedicines have been developed to overcome the …

Oral delivery of biomacromolecules by overcoming biological barriers in the gastrointestinal tract: an update

S Liu, X Wen, X Zhang, S Mao - Expert opinion on drug delivery, 2023 - Taylor & Francis
Introduction Biomacromolecules have proven to be an attractive choice for treating diseases
due to their properties of strong specificity, high efficiency, and low toxicity. Besides greatly …

The spatiotemporal journey of nanomedicines in solid tumors on their therapeutic efficacy

M Qin, H Xia, W Xu, B Chen, Y Wang - Advanced Drug Delivery Reviews, 2023 - Elsevier
The rapid development of nanomedicines is revolutionizing the landscape of cancer
treatment, while effectively delivering them into solid tumors remains a formidable challenge …

Selective organ targeting nanoparticles: from design to clinical translation

J Li, H Wang - Nanoscale Horizons, 2023 - pubs.rsc.org
Targeting nanoparticle is a very promising therapeutic approach that can precisely target
specific sites to treat diseases. Research on nanoscale drug delivery systems has made …

[HTML][HTML] Chitosan-based nano-smart drug delivery system in breast cancer therapy

Y Herdiana, N Wathoni, D Gozali, S Shamsuddin… - Pharmaceutics, 2023 - mdpi.com
Despite recent advances, cancer remains the primary killer on a global scale. Numerous
forms of research have been conducted to discover novel and efficient anticancer …

[HTML][HTML] N-Sulfonyl amidine polypeptides: new polymeric biomaterials with conformation transition responsive to tumor acidity

X Xu, J Ma, A Wang, N Zheng - Chemical Science, 2024 - pubs.rsc.org
Manipulation of pH responsiveness is a frequently employed tactic in the formulation of
trigger-responsive nanomaterials. It offers an avenue for “smart” designs capitalizing on …

Inhaled immunoantimicrobials for the treatment of chronic obstructive pulmonary disease

J Zhu, X Li, Y Zhou, C Ge, X Li, M Hou, Y Wei… - Science …, 2024 - science.org
Effective therapeutic modalities and drug administration strategies for the treatment of
chronic obstructive pulmonary disease (COPD) exacerbations are lacking. Here, mucus and …

Oral delivery of berberine by liver-targeted zwitterionic nanoparticles to overcome multi-intestinal barriers and extend insulin treatment duration

Y Ma, C Li, F Han, Y Liu, UE Hani, Y Zhong… - Chemical Engineering …, 2024 - Elsevier
Oral insulin is a promising strategy due to its favorable patient compliance and repeatable
administration, while it faces with critical problem of multi-intestinal barriers. Moreover, the …

Helical‐Like Assembly of Nateglinide as Coating for Oral Delivery of Insulin and Their Synergistic Prevention of Diabetes Mellitus

Y Li, L Chen, Y Xu, S Li, H Yan, T Chen… - Advanced …, 2023 - Wiley Online Library
Oral delivery of antidiabetic active components promises to free millions of people from daily
suffering who require routine injections. However, oral insulin (Ins) and other short‐acting …