Brain Derived Neurotrophic Factor (BDNF) is a key molecule involved in plastic changes
related to learning and memory. The expression of BDNF is highly regulated, and can lead …

Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central
nervous system and have been shown to play crucial roles in regulating both normal and …

Greatly waned neurogenesis, diminished microvasculature, astrocyte hypertrophy and
activated microglia are among the most conspicuous structural changes in the aged …

Aging is an important determinant of adult hippocampal neurogenesis as the proliferation of
neural stem/precursor cells (NSCs) declines dramatically before middle age. Contrary to …

Impairments in mood and cognitive function are the key brain abnormalities observed in Gulf
war illness (GWI), a chronic multisymptom health problem afflicting∼ 25% of veterans who …

To investigate whether dramatically waned dentate neurogenesis during aging is linked to
diminution in neural stem/progenitor cell (NSC) number, we counted cells immunopositive …

Background and Purpose—Stroke induced by middle cerebral artery occlusion (MCAO)
triggers increased neurogenesis in the damaged striatum and nondamaged hippocampus of …

While it is well known that production of new neurons from neural stem/progenitor cells
(NSC) in the dentate gyrus (DG) diminishes greatly by middle age, the phases and …

The hippocampus is very susceptible to aging. Severely diminished dentate neurogenesis at
middle age is one of the most conspicuous early changes in the aging hippocampus, which …

Activation of endogenous stem cells has been proposed as a novel form of therapy in a
variety of neurologic disorders including traumatic brain injury (TBI). Vascular endothelial …