HIV–host cell interactions

SK Masenga, BC Mweene, E Luwaya, L Muchaili… - Cells, 2023 - mdpi.com
The development of antiretroviral drugs (ARVs) was a great milestone in the management of
HIV infection. ARVs suppress viral activity in the host cell, thus minimizing injury to the cells …

Polysaccharides and their derivatives as potential antiviral molecules

H Claus-Desbonnet, E Nikly, V Nalbantova… - Viruses, 2022 - mdpi.com
In the current context of the COVID-19 pandemic, it appears that our scientific resources and
the medical community are not sufficiently developed to combat rapid viral spread all over …

SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity

R Martínez-Mármol, R Giordano-Santini, E Kaulich… - Science …, 2023 - science.org
Numerous viruses use specialized surface molecules called fusogens to enter host cells.
Many of these viruses, including the severe acute respiratory syndrome coronavirus 2 …

Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review

S Nakahata, D Enriquez-Vera, MI Jahan, K Sugata… - Biomolecules, 2023 - mdpi.com
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL).
HTLV-1 carriers have a lifelong asymptomatic balance between infected cells and host …

Interplay between endogenous and exogenous human retroviruses

E Kyriakou, G Magiorkinis - Trends in Microbiology, 2023 - cell.com
In humans, retroviruses thrive more as symbionts than as parasites. Apart from the only two
modern exogenous human retroviruses (human T-cell lymphotropic and immunodeficiency …

Advances in preventive vaccine development against HTLV-1 infection: A systematic review of the last 35 years

CS Santana, FO Andrade, GCS da Silva… - Frontiers in …, 2023 - frontiersin.org
Introduction The Human T-lymphotropic virus type 1 (HTLV-1) was the first described human
retrovirus. It is currently estimated that around 5 to 10 million people worldwide are infected …

Ultrasensitive quantification of HIV-1 cell-to-cell transmission in primary human CD4+ T cells measures viral sensitivity to broadly neutralizing antibodies

D Mazurov, A Herschhorn - Mbio, 2024 - Am Soc Microbiol
ABSTRACT HIV-1 can efficiently replicate by direct transmission from infected to uninfected
CD4+ T cells at confined local sites designated virological synapses (VSs). VSs are formed …

HTLV‐1 persistent infection and ATLL oncogenesis

X Zuo, R Zhou, S Yang, G Ma - Journal of Medical Virology, 2023 - Wiley Online Library
Human T‐cell leukemia virus type 1 (HTLV‐1) was discovered in the 1980s, but it is
estimated to have been infecting humans for more than ten thousand years. 1 With over 90 …

The past, present, and future of a human T-cell leukemia virus type 1 vaccine

JJ Tu, V Maksimova, L Ratner, AR Panfil - Frontiers in Microbiology, 2022 - frontiersin.org
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic human retrovirus which
causes a lifelong infection. An estimated 5–10 million persons are infected with HTLV-1 …

Unraveling the role of ZNF506 as a human PBS-pro-targeting protein for ERVP repression

Q Wu, L Fang, Y Wang, P Yang - Nucleic Acids Research, 2023 - academic.oup.com
Krüppel-associated box zinc finger proteins (KZFPs) function as a defense mechanism to
maintain the genome stability of higher vertebrates by regulating the transcriptional activities …