We have reviewed current evidence on the therapeutic drug monitoring (TDM) of
mycophenolic acid (MPA) in relationship to drug efficacy and safety. The relationship …

Choosing the right dose of tacrolimus 'adapted to each individual patient'is a central
question after transplantation. The pharmacokinetic behaviour of tacrolimus in paediatric …

Background and Aims: Accurately predicting the response to methotrexate (MTX) in juvenile
idiopathic arthritis (JIA) patients before administration is the key point to improve the …

Background Tacrolimus pharmacokinetics are influenced by age and CYP 3A5 genotype
with CYP 3A5 expressors (CYP 3A5* 1/* 1 or* 1/* 3) being fast metabolizers. However, the …

Abstract Background and Objectives Tacrolimus PR is a new prolonged-release once-daily
formulation of the calcineurin inhibitor tacrolimus, currently used in adult transplant patients …

Background The aim of this study was to develop a population pharmacokinetic model of
tacrolimus in paediatric patients at least 1 year after renal transplantation and simulate …

Cyclosporine (CsA) is characterized by a narrow therapeutic window and high
interindividual pharmacokinetic variability, particularly in juvenile patients. The aims of this …

The calcineurin inhibitor tacrolimus, cornerstone of most immunosuppressive regimens, is a
drug with a narrow therapeutic window: underexposure can lead to allograft rejection and …

Background Tacrolimus has gained acceptance in the management of steroid-resistant
nephrotic syndrome (SRNS) in children. Due to limited data, therapeutic range is …

The advances in high-throughput genomic technologies have improved the understanding
of disease pathophysiology and have allowed a better characterization of drug response …