Lipid regulation of ion channels is largely explored using in silico modeling with minimal
experimentation in intact tissue; thus, the functional consequences of these predicted lipid …

Levels of ATP achieved within the lumen of vessels suggest a key autacoid role. P2Y
receptors on the endothelium may represent the target for ATP, leading to hyperpolarization …

Regulation of the number of Ca 2+-activated K+ channels at the endothelial cell surface
contributes to control of the endothelium-derived hyperpolarizing factor response, although …

Background/Aims: Myoendothelial junctions (MEJs) represent a specialized signaling
domain between vascular smooth muscle cells (VSMC) and endothelial cells (EC). The …

The focus of this review is on local mechanisms modifying arteriolar resistance to match
blood flow to metabolism. In skeletal muscle many local mediators are known, including K+ …

In resistance arteries, endothelial cells (EC) make contact with smooth muscle cells (SMC),
forming myoendothelial junctions (MEJ). Endothelial nitric oxide synthase (eNOS) is present …

The role of vascular gap junctions in the conduction of intercellular Ca 2+ and
vasoconstriction along small resistance arteries is not entirely understood. Some …

Although much physiology in resistance vessels has been attributed to the cytoplasmic
connection between endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) …

Vasomotion describes oscillations of arterial vascular tone due to synchronized changes of
intracellular calcium concentrations. Since increased calcium influx into vascular smooth …

Background and Purpose The calcium‐activated potassium channel KCa 3.1 is expressed
in the vascular endothelium where its activation causes endothelial hyperpolarization and …