Primordial follicles are the starting point of follicular development and the basic functional
unit of female reproduction. Primordial follicles are formed around birth, and most of the …

Male germ cell development depends on multiple biological events that combine epigenetic
reprogramming, cell cycle regulation, and cell migration in a spatio-temporal manner. Sertoli …

Non-obstructive azoospermia (NOA) is a serious cause of male infertility. The Sertoli cell
responds to androgens and takes on roles supporting spermatogenesis, which may cause …

Male infertility is a global concern, with a noticeable increase in the decline of
spermatogenesis and sperm quality. However, there are limited clinically effective …

Sertoli cells are highly polarized testicular cells that provide a nurturing environment for
germ cell development and maturation during spermatogenesis. The class III …

Sertoli cells contribute to the formation of the blood-testis barrier (BTB), which is necessary
for normal spermatogenesis. Recently, microRNAs (miRNAs) have emerged as …

A small GTPase, Cdc42 is evolutionarily one of the most ancient members of the Rho family,
which is ubiquitously expressed and involved in a wide range of fundamental cellular …

There is increasing data showing that some environmental chemicals can increase
susceptibility to follow-up stress or injuries, possibly thereby contributing to certain clinical …

Efferocytosis of non-viable germ cells by Sertoli cells (SCs) constitutes a sentinel for testis
homeostasis, yet how SCs signal for the metabolic and cytoskeletal adaption to this …

Emerging evidence has shown that cell-cell interactions between testicular cells, in
particular at the Sertoli cell-cell and Sertoli-germ cell interface, are crucial to support …