Connexins, pannexins, and their channels in fibroproliferative diseases
B Cogliati, G Mennecier, J Willebrords… - The Journal of …, 2016 - Springer
Cellular and molecular mechanisms of wound healing, tissue repair, and fibrogenesis are
established in different organs and are essential for the maintenance of function and tissue …
established in different organs and are essential for the maintenance of function and tissue …
Gap Junctions or Hemichannel-Dependent and Independent Roles of Connexins in Fibrosis, Epithelial–Mesenchymal Transitions, and Wound Healing
Fibrosis initially appears as a normal response to damage, where activated fibroblasts
produce large amounts of the extracellular matrix (ECM) during the wound healing process …
produce large amounts of the extracellular matrix (ECM) during the wound healing process …
Connexins in epidermal health and diseases: insights into their mutations, implications, and therapeutic solutions
SS Yasarbas, E Inal, MA Yildirim, S Dubrac… - Frontiers in …, 2024 - frontiersin.org
The epidermis, the outermost layer of the skin, serves as a protective barrier against external
factors. Epidermal differentiation, a tightly regulated process essential for epidermal …
factors. Epidermal differentiation, a tightly regulated process essential for epidermal …
Differential susceptibility of C x26 mutations associated with epidermal dysplasias to peptidoglycan derived from Staphylococcus aureus and Staphylococcus …
S Donnelly, G English… - Experimental …, 2012 - Wiley Online Library
Mutations in Connexin26 (C x26) give rise to a spectrum of dominantly inherited
hyperproliferating skin disorders, the severest being keratitis–ichthyosis–deafness (KID) …
hyperproliferating skin disorders, the severest being keratitis–ichthyosis–deafness (KID) …
Human dermal fibroblasts derived from oculodentodigital dysplasia patients suggest that patients may have wound‐healing defects
Oculodentodigital dysplasia (ODDD) is primarily an autosomal dominant human disease
caused by any one of over 60 mutations in the GJA1 gene encoding the gap junction protein …
caused by any one of over 60 mutations in the GJA1 gene encoding the gap junction protein …
The effect of the DLTIDDSYWYRI motif of the human laminin α2 chain on implant osseointegration
HK Kang, OB Kim, SK Min, SY Jung, TK Kwon, BM Min… - Biomaterials, 2013 - Elsevier
Considerable effort has been directed towards replacing lost teeth using tissue-engineering
methods such as titanium implants. A number of studies have tried to modify bioinert titanium …
methods such as titanium implants. A number of studies have tried to modify bioinert titanium …
The lipidated connexin mimetic peptide SRPTEKT-Hdc is a potent inhibitor of Cx43 channels with specificity for the pS368 phospho-isoform
ML Cotter, S Boitano, PD Lampe… - … of Physiology-Cell …, 2019 - journals.physiology.org
Connexin (Cx) mimetic peptides derived from extracellular loop II sequences (eg, Gap27:
SRPTEKTIFII; Peptide5: VDCFLSRPTEKT) have been used as reversible, Cx-specific …
SRPTEKTIFII; Peptide5: VDCFLSRPTEKT) have been used as reversible, Cx-specific …
Topical application of hPDGF-A-modified porcine BMSC and keratinocytes loaded on acellular HAM promotes the healing of combined radiation-wound skin injury in …
G Yan, H Sun, F Wang, J Wang, F Wang… - … journal of radiation …, 2011 - Taylor & Francis
Purpose: To evaluate the efficacy of cultured cutaneous substitute (CCS) in accelerating the
healing of combined radiation-skin wound injury (CRWI) in minipigs. Material and methods …
healing of combined radiation-skin wound injury (CRWI) in minipigs. Material and methods …
Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca2+ signaling in HeLa cells
Gap junction channels (GJCs) and hemichannels (HCs) are composed of protein subunits
termed connexins (Cxs) and are permeable to ions and small molecules. In most organs …
termed connexins (Cxs) and are permeable to ions and small molecules. In most organs …
Lipidated connexin mimetic peptides potently inhibit gap junction-mediated Ca2+-wave propagation
ML Cotter, S Boitano, J Vagner… - American Journal of …, 2018 - journals.physiology.org
Connexin (Cx) mimetic peptides (eg, Gap27: SRPTEKTIFII; Peptide5: VDCFLSRPTEKT)
reversibly inhibit hemichannel (HCh) and gap junction channel (GJCh) function in a …
reversibly inhibit hemichannel (HCh) and gap junction channel (GJCh) function in a …