Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …

WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Transforming growth factor-β (TGF-β) is widely recognized as a core pathway of fibrosis.
Inhibition of TGF-β signaling may thus offer potential for antifibrotic therapies. Long-term …

Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the
pathogenesis of various chronic diseases and aging-related organ failure to fully control …

The WNT signaling pathways are major regulators of organ development. Ample research
over the past few decades revealed that these pathways are critically involved in adult tissue …

Chronic diseases account for approximately 45% of all deaths in developed countries and
are particularly prevalent in countries with the most sophisticated and robust public health …

Vascular calcification, a common pathological basis of vascular disease, is caused by
various diseases and is an independent risk factor for cardiovascular events. Therefore …

Liver fibrosis is a life-threatening disease, with challenging morbidity and mortality for
healthcare systems worldwide. It imparts an enormous economic burden to societies …