There is growing recognition that B cell contributions to normal immune responses extend
well beyond their potential to become antibody-producing cells, including roles at the innate …

Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality
and disability in allogeneic hematopoietic cell transplantation recipients and a major …

Chronic autoimmune diseases, and in particular Systemic Lupus Erythematosus (SLE), are
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …

Acute systemic lupus erythematosus (SLE) courses with surges of antibody-secreting cells
(ASCs) whose origin, diversity and contribution to serum autoantibodies remain unknown …

The discovery that lymphocyte subpopulations participate in distinct components of the
immune response focused attention onto the origins and function of lymphocytes more than …

Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

B cells differentiate from pluripotent hematopoietic stem cells (pHSCs) in a series of distinct
stages. During early embryonic development, pHSCs migrate into the fetal liver, where they …

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-
tolerance with activation of autoreactive T and B cells leading to production of pathogenic …

Objective To study antibody‐independent contributions of B cells to inflammatory disease
activity, and the immune consequences of B‐cell depletion with rituximab, in patients with …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) that is characterised pathologically by demyelination, gliosis, neuro-axonal damage …