Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis
SK Mohanta, C Yin, L Peng, P Srikakulapu… - Circulation …, 2014 - Am Heart Assoc
Tertiary lymphoid organs emerge in tissues in response to nonresolving inflammation.
Recent research characterized artery tertiary lymphoid organs in the aorta adventitia of aged …
Recent research characterized artery tertiary lymphoid organs in the aorta adventitia of aged …
[HTML][HTML] Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus
LL Teichmann, D Schenten, R Medzhitov… - Immunity, 2013 - cell.com
Detection of self nucleic acids by Toll-like receptors (TLR) preciptates autoimmune diseases,
including systemic lupus erythematosus (SLE). It remains unknown how TLR signals in …
including systemic lupus erythematosus (SLE). It remains unknown how TLR signals in …
Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential
Atherosclerosis is a chronic inflammatory disease that is mediated by innate and adaptive
immune responses. The disease is characterized by sub-endothelial accumulation and …
immune responses. The disease is characterized by sub-endothelial accumulation and …
[HTML][HTML] IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate
M Noviski, JL Mueller, A Satterthwaite… - Elife, 2018 - elifesciences.org
Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding
domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B …
domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B …
BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact
JL Scholz, JE Crowley, MM Tomayko… - Proceedings of the …, 2008 - National Acad Sciences
We have used an inhibiting antibody to determine whether preimmune versus antigen-
experienced B cells differ in their requisites for BLyS, a cytokine that controls differentiation …
experienced B cells differ in their requisites for BLyS, a cytokine that controls differentiation …
Mechanisms of environmental influence on human autoimmunity: a National Institute of Environmental Health Sciences expert panel workshop
The mechanisms leading to autoimmune diseases remain largely unknown despite
numerous lines of experimental inquiry and epidemiological evidence. The growing number …
numerous lines of experimental inquiry and epidemiological evidence. The growing number …
[HTML][HTML] The autoimmune ecology
JM Anaya, C Ramirez-Santana, MA Alzate… - Frontiers in …, 2016 - frontiersin.org
Autoimmune diseases (ADs) represent a heterogeneous group of disorders that affect
specific target organs or multiple organ systems. These conditions share common …
specific target organs or multiple organ systems. These conditions share common …
[HTML][HTML] Lrig1-expression confers suppressive function to CD4+ cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis
JS Moon, CC Ho, JH Park, K Park, BY Shin… - Nature …, 2023 - nature.com
Regulatory T cells (Treg) are CD4+ T cells with immune-suppressive function, which is
defined by Foxp3 expression. However, the molecular determinants defining the …
defined by Foxp3 expression. However, the molecular determinants defining the …
[HTML][HTML] Aberrant activation of immune and non-immune cells contributes to joint inflammation and bone degradation in rheumatoid arthritis
KS Nandakumar, Q Fang, I Wingbro Ågren… - International Journal of …, 2023 - mdpi.com
Abnormal activation of multiple immune and non-immune cells and proinflammatory factors
mediate the development of joint inflammation in genetically susceptible individuals …
mediate the development of joint inflammation in genetically susceptible individuals …
[HTML][HTML] MicroRNAs prevent the generation of autoreactive antibodies
MicroRNAs have been shown to be critical for a number of aspects of immune system
regulation and function. Here, we have examined the role of microRNAs in terminal B cell …
regulation and function. Here, we have examined the role of microRNAs in terminal B cell …