CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted'state
associated with elevated expression of inhibitory receptors, including PD-1, and impaired …

Progenitor-like CD8+ T cells mediate long-term immunity to chronic infection and cancer and
respond potently to immune checkpoint blockade. These cells share transcriptional …

The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …

Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …

The differentiation of human memory CD8 T cells is not well understood. Here we address
this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity …

Protective immunity against pathogens depends on the efficient generation of functionally
diverse effector and memory T lymphocytes. However, whether plasticity during effector-to …

During chronic viral infections and in cancer, T cells become dysfunctional, a state known as
T cell exhaustion. Although it is well recognized that memory CD8 T cells account for the …

Recent progress in cancer immunotherapy emphasizes the importance of understanding
immune-regulatory pathways in tumours. Dysfunction of antitumour T cells may be due to …

Tissue-resident memory T cells (TRM cells) provide superior protection against infection in
extralymphoid tissues. Here we found that CD103+ CD8+ TRM cells developed in the skin …

During an infection, T cells can differentiate into multiple types of effector and memory T
cells, which help to mediate pathogen clearance and provide long-term protective immunity …