Abstract Bcl-6 and Blimp-1 have recently been identified as key transcriptional regulators of
effector and memory differentiation in CD4+ T cells and CD8+ T cells. Bcl-6 and Blimp-1 …

Memory CD8+ T cells are critical for long-term immunity, but the genetic pathways governing
their formation remain poorly defined. This study shows that the IL-10-IL-21-STAT3 pathway …

Central memory T (TCM) cells in lymph nodes (LNs) and resident memory T (TRM) cells in
peripheral tissues have distinct roles in protective immunity,,,,. Both are generated after …

The mechanisms underpinning integration of instructions that program naive CD8+ T cells
for effector and/or memory differentiation are not well understood. Herein, we demonstrate …

T cell exhaustion is common during chronic infections and can prevent optimal immunity.
Although recent studies have demonstrated the importance of inhibitory receptors and other …

The outcome of an infection with any given pathogen varies according to the dosage and
route of infection, but, in addition, the physiological state of the host can determine the …

ABSTRACT T cell exhaustion and loss of memory potential occur during many chronic viral
infections and cancer. We investigated when during chronic viral infection virus-specific CD8 …

Particulate vaccines are emerging promising technologies for the creation of tunable
prophylactics against a wide variety of conditions. Vesicular and solid biodegradable …

CD8+ T cells are the key executioners of the adaptive immune arm, which mediates
antitumor and antiviral immunity. Naïve CD8+ T cells develop in the thymus and are quickly …

The adaptive immune response meets the needs of the organism to generate effector cells
capable of controlling pathogens but also leads to production of memory cells, which …