[HTML][HTML] Matrix metalloproteinase 9 (MMP9) limits reactive oxygen species (ROS) accumulation and DNA damage in colitis-associated cancer

L Walter, B Canup, A Pujada, TA Bui, B Arbasi… - Cell death & …, 2020 - nature.com
Colitis-associated cancer (CAC) is a subtype of colon cancer that is driven by chronic
inflammation and is prevalent in chronic ulcerative colitis patients. The development of CAC …

Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease

Y Du, L Rong, Y Cong, L Shen, N Zhang… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Inflammatory bowel disease (IBD) is a systemic disease with immune
abnormalities that can affect the entire digestive tract. A high percentage of patients with IBD …

[HTML][HTML] Perinatal tissue-derived exosomes ameliorate colitis in mice by regulating the Foxp3+ Treg cells and gut microbiota

Y Yan, K Li, J Jiang, L Jiang, X Ma, F Ai, S Qiu… - Stem Cell Research & …, 2023 - Springer
Background The capacity of self-renewal and multipotent differentiation makes
mesenchymal stem cells (MSC) one of the most widely investigated cell lines in preclinical …

Ginsenoside Rk3 alleviated DSS-induced ulcerative colitis by protecting colon barrier and inhibiting NLRP3 inflammasome pathway

M Tian, P Ma, Y Zhang, Y Mi, D Fan - International Immunopharmacology, 2020 - Elsevier
Ginsenosides have a variety of pharmacological activities, including immunomodulatory,
antitumor and anti-inflammatory activities. However, the effect of Rk3 on ulcerative colitis has …

Recent advances in gut microbiota mediated therapeutic targets in inflammatory bowel diseases: emerging modalities for future pharmacological implications

M Shamoon, NM Martin, CL O'Brien - Pharmacological Research, 2019 - Elsevier
The inflammatory bowel diseases (IBDs) are chronic inflammatory conditions, which are
increasing in prevalence worldwide. The IBDs are thought to result from an aberrant immune …

New insights into the role of oral microbiota dysbiosis in the pathogenesis of inflammatory bowel disease

Y Qi, H Wu, Z Yang, Y Zhou, L Jin, M Yang… - Digestive Diseases and …, 2022 - Springer
Inflammatory bowel disease (IBD) is a group of chronic intestinal inflammatory disorders with
a prolonged duration characterized by recurrent relapse and remission. The exact etiology …

The roles of different Bacteroides fragilis strains in protecting against DSS-induced ulcerative colitis and related functional genes

C Wang, S Li, K Hong, L Yu, F Tian, J Zhao, H Zhang… - Food & Function, 2021 - pubs.rsc.org
The role of supplementation with different Bacteroides fragilis (B. fragilis) strains in
alleviating ulcerative colitis (UC) is unclear due to the controversial results from animal …

Quercetin serves as the major component of Xiang-lian Pill to ameliorate ulcerative colitis via tipping the balance of STAT1/PPARγ and dictating the alternative …

H Zhou, C Yang, J Li, Y He, Y Huang, R Qin… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance The traditional Chinese herbal formula, Xiang-
lian Pill (XLP), is commonly prescribed for ulcerative colitis (UC) patients to relieve their …

Identification of the key physiological characteristics of Lactobacillus plantarum strains for ulcerative colitis alleviation

Y Liu, Y Sheng, Q Pan, Y Xue, L Yu, F Tian, J Zhao… - Food & function, 2020 - pubs.rsc.org
Lactobacillus plantarum is a probiotic that is widely used to prevent ulcerative colitis (UC).
However, the effects of this species are strain-specific. We believe that the physiological …

[HTML][HTML] Peroxisome elevation induces stem cell differentiation and intestinal epithelial repair

G Du, L Xiong, X Li, Z Zhuo, X Zhuang, Z Yu, L Wu… - Developmental cell, 2020 - cell.com
Epithelial-repair-dependent mucosal healing (MH) is associated with a more favorable
prognosis for patients with inflammatory bowel disease (IBD). MH is accomplished via repair …