Objectives: We sought to systematically review and meta-analyze the available data on the
association between timing of antibiotic administration and mortality in severe sepsis and …

Abstract The Surviving Sepsis Campaign recommends immediate antibiotics for all patients
with suspected sepsis and septic shock, ideally within 1 hour of recognition. Immediate …

Background We evaluated the associations between the neutrophil-to-lymphocyte ratio
(NLR) or changes in NLR and outcomes in septic patients. Methods Patients who met the …

Methods Studies were identified via a PubMed literature search (from 1966 to January
2018). Search terms included microbial sensitivity tests, microbial drug resistance, and anti …

Background Rapid initiation of antibiotic treatment is considered crucial in patients with
severe infections such as septic shock and bacterial meningitis, but may not be as important …

Study objective We determine the diagnostic performance of positive Quick Sequential
Organ Failure Assessment (qSOFA) scores for predicting 28-day mortality among critically ill …

Background and objectives: Oxidative stress (OS) participates in the pathophysiology of
septic shock, which leads to multiple organ failure (MOF), ischemia-reperfusion injury, and …

Objectives To review the impact of the timeliness of antibiotic therapy on the outcome of
patients with sepsis or septic shock. Methods We searched MEDLINE, EMBASE, the …

Background Sepsis is an important global healthcare problem that is a key challenge faced
by healthcare professionals face worldwide. One key effort aimed at reducing the global …

Objectives: We evaluated central venous oxygen saturation (Scvo 2) and lactate levels as a
combination measure to predict mortality in patients with severe sepsis or septic shock …