[HTML][HTML] GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease

J Jiménez-Balado, TS Eich - Seminars in cell & developmental biology, 2021 - Elsevier
In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

Shared functions of perirhinal and parahippocampal cortices: implications for cognitive aging

SN Burke, LS Gaynor, CA Barnes, RM Bauer… - Trends in …, 2018 - cell.com
A predominant view of perirhinal cortex (PRC) and postrhinal/parahippocampal cortex
(POR/PHC) function contends that these structures are tuned to represent objects and …

Functional imbalance of anterolateral entorhinal cortex and hippocampal dentate/CA3 underlies age-related object pattern separation deficits

ZM Reagh, JA Noche, NJ Tustison, D Delisle… - Neuron, 2018 - cell.com
The entorhinal cortex (EC) is among the earliest brain areas to deteriorate in Alzheimer's
disease (AD). However, the extent to which functional properties of the EC are altered in the …

Predicting age from cortical structure across the lifespan

CR Madan, EA Kensinger - European Journal of Neuroscience, 2018 - Wiley Online Library
Despite interindividual differences in cortical structure, cross‐sectional and longitudinal
studies have demonstrated a large degree of population‐level consistency in age‐related …

Scan once, analyse many: using large open-access neuroimaging datasets to understand the brain

CR Madan - Neuroinformatics, 2022 - Springer
We are now in a time of readily available brain imaging data. Not only are researchers now
sharing data more than ever before, but additionally large-scale data collecting initiatives …

[HTML][HTML] The impact of multimodal cognitive rehabilitation on executive functions in older adults with traumatic brain injury

E Cisneros, V Beauséjour, E De Guise… - Annals of physical and …, 2021 - Elsevier
Objectives This study evaluated the impact of a 12-week, 24-session multimodal group
cognitive rehabilitation intervention, the Cognitive Enrichment Program (CEP), on executive …

Reaching the goal: Superior navigators in late adulthood provide a novel perspective into successful cognitive aging

R Zhou, T Belge, T Wolbers - Topics in Cognitive Science, 2023 - Wiley Online Library
Normal aging is typically associated with declines in navigation and spatial memory abilities.
However, increased interindividual variability in performance across various …

Age-related changes in lateral entorhinal and CA3 neuron allocation predict poor performance on object discrimination

AP Maurer, SA Johnson, AR Hernandez… - Frontiers in Systems …, 2017 - frontiersin.org
Age-related memory deficits correlate with dysfunction in the CA3 subregion of the
hippocampus, which includes both hyperactivity and overly rigid activity patterns. While …

Age-related change in episodic memory: role of functional and structural connectivity between the ventral posterior cingulate and the parietal cortex

M Edde, B Dilharreguy, G Theaud, S Chanraud… - Brain Structure and …, 2020 - Springer
While the neural correlates of age-related episodic memory decline have been extensively
studied, the precise involvement of the Posterior Cingulate Cortex (PCC) and posterior …

[HTML][HTML] Brain age of rhesus macaques over the lifespan

YS Liu, M Baxi, CR Madan, K Zhan, N Makris… - Neurobiology of …, 2024 - Elsevier
Through the application of machine learning algorithms to neuroimaging data the brain age
methodology was shown to provide a useful individual-level biological age prediction and …