Oligonucleotides can be used to modulate gene expression via a range of processes
including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation …

Dendritic polymers have highly branched three‐dimensional architectures, the fourth type
apart from linear, cross‐linked, and branched one. They possess not only a large number of …

Polymer grafting is a technique to improve the morphology, chemical, and physical
properties of the polymer. This technique has the potential to improve the existing …

Gene-based therapies have emerged as a new modality for combating a myriad of currently
incurable diseases. However, the fragile nature of gene therapeutics has significantly …

Chemotherapy is the first choice in the treatment of cancer and is always preferred to other
approaches such as radiation and surgery, but it has never met the need of patients for a …

Carbosilane dendrimers are a particular type of dendrimer structure that has been used as
delivery vehicles for drugs and nucleic acids. They have a defined structure according to …

Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their
translation to clinical practice. Key issues concern the specificity of the targets, the delivery of …

Over the last decades, nanotechnology applied in medicine (nanomedicine) has sparked
great interest from the scientific community, thanks to the possibility to engineer …

Lung diseases are a leading cause of mortality worldwide and there exists urgent need for
new therapies. Approval of the first siRNA treatments in humans has opened the door for …

Dendrimers in nanobiomedicine have attracted attention to overcome the biological barriers
because of their suitable characteristics such as nanosize, hyperbranching polymeric …