Poor medication adherence is a pervasive issue with considerable health and
socioeconomic consequences. Although the underlying reasons are generally understood …

Background Depression and anxiety are prevalent psychiatric disorders that carry significant
morbidity. Pharmacological and psychosocial interventions are used to manage these …

Objective: Postpartum depression (PPD) is a common perinatal complication with adverse
maternal and infant outcomes. This study investigated the efficacy and safety of zuranolone …

Background About one-third of patients with depression fail to achieve remission despite
treatment with multiple antidepressants and are considered to have treatment-resistant …

Major depressive disorder (MDD) is a leading cause of suicide in the world. Monoamine-
based antidepressant drugs are a primary line of treatment for this mental disorder, although …

Hippocampal neurogenesis continues throughout life and has been suggested to play an
essential role in maintaining spatial cognitive function under physiological conditions. An …

Psychedelic therapy shows promise as a novel intervention for a wide range of mental
health concerns but its therapeutic action is incompletely understood. In line with …

Major depressive disorder has become a global public health problem of serious concern.
Most of the clinical antidepressants are developed under the classic “monoamine …

Current therapeutic options for major depressive disorder (MDD) and bipolar disorder (BD)
are associated with a lag of onset that can prolong distress and impairment for patients, and …

We present a review and analysis of the ethical considerations in off-label ketamine use for
severe, treatment-resistant depression. The analysis of ethical considerations is …