Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …

Therapeutic drug monitoring (TDM) opens the door to personalized medicine, yet it is
infrequently applied to β‐lactam antibiotics, one of the most commonly prescribed drug …

Purpose Individualising drug dosing using model-informed precision dosing (MIPD) of beta-
lactam antibiotics and ciprofloxacin has been proposed as an alternative to standard dosing …

Beta-lactams remain a critical member of our antibiotic armamentarium and are among the
most commonly prescribed antibiotic classes in the inpatient setting. For these agents, the …

Appropriate antibiotic treatment for critically ill patients with serious Gram-negative infections
in the intensive care unit is crucial to minimize morbidity and mortality. Several new …

What is known and objective Meropenem, a carbapenem antibiotic, is widely prescribed for
the treatment of life‐threatening infections. The main parameter associated with its …

A fundamental step in the successful management of sepsis and septic shock is early
empiric antimicrobial therapy. However, for this to be effective, several decisions must be …

Rationale: Data suggest that altered antimicrobial concentrations are likely during
extracorporeal membrane oxygenation (ECMO). Objectives: The primary aim of this analysis …

The pathophysiology of sepsis alters drug pharmacokinetics, resulting in inadequate drug
exposure and target-site concentration. Suboptimal exposure leads to treatment failure and …

Optimal pharmacotherapy in pediatric patients with suspected infections requires
understanding and integration of relevant data on the antibiotic, bacterial pathogen, and …