Mitochondria in health, disease, and aging

JS Harrington, SW Ryter, M Plataki… - Physiological …, 2023 - journals.physiology.org
Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Reinforcement learning in healthcare: A survey

C Yu, J Liu, S Nemati, G Yin - ACM Computing Surveys (CSUR), 2021 - dl.acm.org
As a subfield of machine learning, reinforcement learning (RL) aims at optimizing decision
making by using interaction samples of an agent with its environment and the potentially …

Plants as sources of anti-inflammatory agents

CR Nunes, M Barreto Arantes… - Molecules, 2020 - mdpi.com
Plants represent the main source of molecules for the development of new drugs, which
intensifies the interest of transnational industries in searching for substances obtained from …

The artificial intelligence clinician learns optimal treatment strategies for sepsis in intensive care

M Komorowski, LA Celi, O Badawi, AC Gordon… - Nature medicine, 2018 - nature.com
Sepsis is the third leading cause of death worldwide and the main cause of mortality in
hospitals,–, but the best treatment strategy remains uncertain. In particular, evidence …

Sepsis associated acute kidney injury

JT Poston, JL Koyner - Bmj, 2019 - bmj.com
Sepsis is defined as organ dysfunction resulting from the host's deleterious response to
infection. One of the most common organs affected is the kidneys, resulting in sepsis …

What are the respiratory effects of e-cigarettes?

JE Gotts, SE Jordt, R McConnell, R Tarran - bmj, 2019 - bmj.com
Electronic cigarettes (e-cigarettes) are alternative, non-combustible tobacco products that
generate an inhalable aerosol containing nicotine, flavors, propylene glycol, and vegetable …

Living leukocyte‐based drug delivery systems

Y Chen, D Qin, J Zou, X Li, XD Guo, Y Tang… - Advanced …, 2023 - Wiley Online Library
Leukocytes play a vital role in immune responses, including defending against invasive
pathogens, reconstructing impaired tissue, and maintaining immune homeostasis. When the …

Intrinsic radical species scavenging activities of tea polyphenols nanoparticles block pyroptosis in endotoxin-induced sepsis

Y Chen, R Luo, J Li, S Wang, J Ding, K Zhao, B Lu… - Acs Nano, 2022 - ACS Publications
Sepsis, a life-threating illness caused by deregulated host immune responses to infections,
is characterized by overproduction of multiple reactive oxygen and nitrogen species (RONS) …

Innate immune receptors in platelets and platelet-leukocyte interactions

PRB Dib, AC Quirino-Teixeira, LB Merij… - Journal of Leucocyte …, 2020 - academic.oup.com
Platelets are chief cells in hemostasis. Apart from their hemostatic roles, platelets are major
inflammatory effector cells that can influence both innate and adaptive immune responses …

Emerging pyroptosis-engineered nanobiotechnologies regulate cancers and inflammatory diseases: A double-edged sword

Y Zhang, C Fang, W Zhang, K Zhang - Matter, 2022 - cell.com
Pyroptosis is closely associated with tumors and inflammatory diseases. By enhancing
pyroptosis, direct and immune-response-triggered deaths of tumor cells are increased …