Chemokines are an indispensable component of our immune system through the regulation
of directional migration and activation of leukocytes. CXCL8 is the most potent human …

Osteoarthritis (OA) is a common degenerative joint disease that often involves progressive
cartilage degeneration and bone destruction of subchondral bone. At present, clinical …

Excessive mechanical strain is the prominent risk factor for osteoarthritis (OA), causing
cartilage destruction and degeneration. However, the underlying molecular mechanism …

Arteriovenous malformations (AVMs) are fast-flow vascular malformations and refer to
important causes of intracerebral haemorrhage in young adults. Getting deep insight into the …

Cartilage organoids have emerged as powerful modelling technology for recapitulation of
joint embryonic events, and cartilage regeneration, as well as pathophysiology of cartilage …

The proinflammatory cytokines and arachidonic acid (AA)-derived eicosanoids play a key
role in cartilage degeneration in osteoarthritis (OA). The lysophosphatidylcholine …

Sensing acidosis is an important somatosensory function in responses to ischemia,
inflammation, and metabolic alteration. Accumulating evidence has shown that acidosis is …

Extracellular matrix (ECM) is a three-dimensional network entity composed of extracellular
macromolecules. ECM in synovium not only supports the structural integrity of synovium, but …

The NLRP3 inflammasome functions as an inflammatory driver, but its relationship with lipid
metabolic changes in early sepsis remains unclear. Here, we found that GITR expression in …

Abstract Changes in extracellular proton concentrations occur in a variety of tissues over a
range of timescales under physiological conditions and also accompany virtually all …