[HTML][HTML] Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID …

AM Chaves-Filho, O Braniff, A Angelova, Y Deng… - Brain Research …, 2023 - Elsevier
After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized
that a significant portion of the affected individuals developed long-term debilitating …

Ether lipid-mediated antioxidant defense in Alzheimer's disease

M Jové, N Mota-Martorell, È Obis, J Sol, M Martín-Garí… - Antioxidants, 2023 - mdpi.com
One of the richest tissues in lipid content and diversity of the human body is the brain. The
human brain is constitutively highly vulnerable to oxidative stress. This oxidative stress is a …

Fundamental neurochemistry review: Old brain stories‐Influence of age and sex on the neurodegeneration‐associated lipid changes

L Cuenca‐Bermejo, A Prinetti… - Journal of …, 2023 - Wiley Online Library
Brain aging is a naturally occurring process resulting in the decline of cognitive functions
and increased vulnerability to develop age‐associated disorders. Fluctuation in lipid species …

Mass spectrometry imaging as an emerging tool for studying metabolism in human brain organoids

G Cappuccio, SM Khalil, S Osenberg, F Li… - Frontiers in Molecular …, 2023 - frontiersin.org
Human brain organoids are emerging models to study human brain development and
pathology as they recapitulate the development and characteristics of major neural cell …

Effects of high-sugar, high-cholesterol, and high-fat diet on phospholipid profile of mouse tissues with a focus on the mechanism of plasmalogen synthesis

X Fan, R Wang, Y Song, Z Wang, X Wang, Y Liu… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Abstract High-sugar diet (HSD), high-cholesterol diet (HCD), and high-fat diet (HFD) all
modulate the levels of lipids. However, there is a lack of comparative data on the effects of …

[HTML][HTML] Alterations to sphingolipid metabolism from antipsychotic administration in healthy volunteers are restored following the use of cannabidiol

B Jieu, EB Sykorova, C Rohleder, E Marcolini… - Psychiatry …, 2024 - Elsevier
Randomized clinical trials substantiate cannabidiol (CBD) as a next-generation
antipsychotic, effective in alleviating positive and negative symptoms associated with …

The sphingosine 1‐phosphate analogue, FTY720, modulates the lipidomic signature of the mouse hippocampus

DM Magalhães, NA Stewart, M Mampay… - Journal of …, 2024 - Wiley Online Library
The small‐molecule drug, FTY720 (fingolimod), is a synthetic sphingosine 1‐phosphate
(S1P) analogue currently used to treat relapsing–remitting multiple sclerosis in both adults …

Spatial lipidomics maps brain alterations associated with mild traumatic brain injury

D Leontyev, AN Pulliam, X Ma, DA Gaul… - Frontiers in …, 2024 - frontiersin.org
Traumatic brain injury (TBI) is a global public health problem with 50–60 million incidents
per year, most of which are considered mild (mTBI) and many of these repetitive (rmTBI) …

Solitary and Synergistic Effects of Different Hydrophilic and Hydrophobic Phospholipid Moieties on Rat Behaviors

S Kikuchi, Y Iwasaki, M Yoshioka, K Hino, S Morita… - Pharmaceutics, 2024 - mdpi.com
Glycerophospholipids have hydrophobic and hydrophilic moieties. Previous studies suggest
that phospholipids with different moieties have different effects on rodent behavior; however …

Per-and Polyfluoroalkyl Substances: Impacts on Morphology, Behavior and Lipid Levels in Zebrafish Embryos

J Albers, J Mylroie, A Kimble, C Steward, K Chapman… - Toxics, 2024 - mdpi.com
The presence of per-and polyfluoroalkyl substances (PFASs) in aquatic environments is
often persistent and widespread. Understanding the potential adverse effects from this group …